|Title:||Diffusion MRI connectometry automatically reveals affected fiber pathways in individuals with chronic stroke||Authors:||Yeh F.-C.
|Issue Date:||2013||Journal Volume:||2||Journal Issue:||1||Start page/Pages:||912-921||Source:||NeuroImage: Clinical||Abstract:||
Building a human connectome database has recently attracted the attention of many researchers, although its application to individual subjects has yet to be explored. In this study, we acquired diffusion spectrum imaging of 90 subjects and showed that this dataset can be used as a norm to examine pathways with deviant connectivity in individuals. This analytical approach, termed diffusion MRI connectometry, was realized by reconstructing patient data to a common stereotaxic space and calculating the percentile rank of the diffusion quantities with respect to those of the norm. The affected tracks were constructed with deterministic tractography using the local tract orientations with substantially low percentile ranks as seeds. To demonstrate the performance of the connectometry, we applied it to 7 patients with chronic stroke and compared the results with lesions shown on T2-weighted images, apparent diffusion coefficient (ADC) maps, and fractional anisotropy (FA) maps, as well as clinical manifestations. The results showed that the affected tracks revealed by the connectometry corresponded well with the stroke lesions shown on T2-weighted images. Moreover, while the T2-weighted images, as well as the ADC and FA maps, showed only the stroke lesions, connectometry revealed entire affected tracks, a feature that is potentially useful for diagnostic or prognostic evaluation. This unique capability may provide personalized information regarding the structural connectivity underlying brain development, plasticity, or disease in each individual subject. ? 2013 The Authors.
|ISSN:||2213-1582||DOI:||10.1016/j.nicl.2013.06.014||SDG/Keyword:||adult; aged; arcuate fasciculus; article; basal ganglion; capsula interna; cerebrovascular accident; chronic disease; clinical article; controlled study; corpus callosum; diffusion coefficient; diffusion weighted imaging; female; fractional anisotropy; frontal cortex; human; image reconstruction; lacunar stroke; leukoaraiosis; male; motor performance; occipital cortex; parietal cortex; plasticity; priority journal; prognosis; pyramidal tract; temporal cortex; tractography; white matter
|Appears in Collections:||物理治療學系所|
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