https://scholars.lib.ntu.edu.tw/handle/123456789/506620
標題: | Use of low-frequency repetitive transcranial magnetic stimulation to reduce context-dependent learning in people with Parkinson's disease | 作者: | YA-YUN LEE Fisher B.E. |
公開日期: | 2018 | 出版社: | Edizioni Minerva Medica | 卷: | 54 | 期: | 4 | 起(迄)頁: | 560-567 | 來源出版物: | European Journal of Physical and Rehabilitation Medicine | 摘要: | BACKGROUND: Compared with age-matched non-disabled adults, people with Parkinson's disease (PD) demonstrated greater context-dependent learning, a phenomenon in which an individual shows inferior motor performance when the testing environmental context is different from the original practice context. Additionally, enhanced context-dependency has been shown to be associated with an increased activation of the dorsolateral prefrontal cortex (DLPFC). AIM: This study aimed to determine whether context-dependent learning in people with PD could be reduced by decreasing DLPFC activation with low frequency repetitive transcranial magnetic stimulation (rTMS). DESIGN: Quasi-experimental pre-/post-test controlled study. SETTING: University laboratory. POPULATION : Twenty-seven participants (18 individuals with PD and 9 age-matched non-disabled adults) were recruited into the PD, PD- rTMS (PD participants who received low frequency rTMS), and Control groups. METHODS: All participants practiced a finger sequence task containing 3 sequences embedded within specific contexts (colored circles and spatial location on a computer screen) on the first day. On day 2, the participants were tested under the SWITCH and SAME conditions. In the SWITCH condition, the sequence-context association changed from that of practice; in the SAME condition, the sequence-context association remained the same as practice. The PD-rTMS group received 1 H z rTMS applied over the left DLPFC on the second day before the testing conditions. Switch cost, the performance difference between the SWITCH and SAME conditions, was calculated to indicate context-dependency. RESULTS: All participants improved throughout practice on the first day. Analysis of the switch cost revealed a significant group main effect (P=0.050). Post-hoc analysis revealed that the PD-rTMS group had significantly smaller switch cost than the PD group (P=0.031) but not the control group. CONCLUSIONS: Low frequency rTMS applied over DLPFC reduced context-dependency in people with PD. CLINICAL REHABILITATION IMPACT: The findings provide a preliminary evidence of using low frequency rTMS as an adjuvant intervention approach to facilitate individuals with PD to generalize a learned motor task from one environmental context to another. ? 2017 EDIZIONI MINERVA MEDICA. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049670589&doi=10.23736%2fS1973-9087.17.04723-2&partnerID=40&md5=74cadefee640aec3d41424604b09cf7d https://scholars.lib.ntu.edu.tw/handle/123456789/506620 |
ISSN: | 1973-9087 | DOI: | 10.23736/S1973-9087.17.04723-2 | SDG/關鍵字: | aged; case control study; cognition; comparative study; disability; female; human; learning; male; middle aged; Parkinson disease; pathophysiology; physiology; prefrontal cortex; procedures; psychomotor performance; reference value; task performance; transcranial magnetic stimulation; Aged; Case-Control Studies; Cognition; Disability Evaluation; Female; Humans; Learning; Male; Middle Aged; Parkinson Disease; Prefrontal Cortex; Psychomotor Performance; Reference Values; Task Performance and Analysis; Transcranial Magnetic Stimulation |
顯示於: | 物理治療學系所 |
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