https://scholars.lib.ntu.edu.tw/handle/123456789/506826
標題: | Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis | 作者: | Higuchi W. Hung W.-C. Takano T. Iwao Y. Ozaki K. Isobe H. LEE-JENE TENG Shimazaki T. Honda A. Higashide M. Hanaki H. Yamamoto T. |
關鍵字: | Cellulitis; Child; Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA); Panton-Valentine leucocidin (PVL) | 公開日期: | 2010 | 卷: | 16 | 期: | 2 | 起(迄)頁: | 144_149 | 來源出版物: | Journal of Infection and Chemotherapy | 摘要: | Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Japanese boy. This MRSA was PVL-positive and belonged to the Taiwanese multiple drug-resistant CA-MRSA clone with the genotype of ST59, staphylococcal cassette chromosome mec (SCCmec) VII (SCCmecV, according to recent reclassification), agr1a (a novel agr1 subtype), and SaPI (which carried seb1, a newly designated variant seb gene). This study demonstrates the first isolation of the Taiwanese PVL-positive ST59 MRSA clone in Japan. The data also demonstrate novel subtypes in agr1 and seb and suggest that a combination of agr1a, seb1, and PVL could contribute to cellulitis (and its recurrence). Recently, a variety of PVL-positive MRSA clones are accumulating in Japan. ? 2010 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/506826 | ISSN: | 1341-321X | DOI: | 10.1007/s10156-010-0029-9 | SDG/關鍵字: | agr1 protein; agr1a protein; ampicillin; bacterial protein; biapenem; cefazolin; cefdinir; cefotaxime; cefotiam; cefoxitin; cefpirome; flomoxef; gentamicin; habekacin; imipenem; kanamycin; latamoxef; linezolid; macrolide; mec protein; meropenem; oxacillin; panipenem; Panton Valentine leukocidin; quinoline derived antiinfective agent; seb1 protein; streptomycin; teicoplanin; unclassified drug; unindexed drug; vancomycin; abdomen; antibiotic sensitivity; article; bacterium isolation; case report; cellulitis; child; clone; gene cassette; genotype; human; Japanese; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; multidrug resistance; nonhuman; nucleotide sequence; school child; Taiwan |
顯示於: | 醫學檢驗暨生物技術學系 |
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