Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis
Journal
Journal of Infection and Chemotherapy
Journal Volume
16
Journal Issue
2
Pages
144_149
Date Issued
2010
Author(s)
Higuchi W.
Hung W.-C.
Takano T.
Iwao Y.
Ozaki K.
Isobe H.
Shimazaki T.
Honda A.
Higashide M.
Hanaki H.
Yamamoto T.
Abstract
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Japanese boy. This MRSA was PVL-positive and belonged to the Taiwanese multiple drug-resistant CA-MRSA clone with the genotype of ST59, staphylococcal cassette chromosome mec (SCCmec) VII (SCCmecV, according to recent reclassification), agr1a (a novel agr1 subtype), and SaPI (which carried seb1, a newly designated variant seb gene). This study demonstrates the first isolation of the Taiwanese PVL-positive ST59 MRSA clone in Japan. The data also demonstrate novel subtypes in agr1 and seb and suggest that a combination of agr1a, seb1, and PVL could contribute to cellulitis (and its recurrence). Recently, a variety of PVL-positive MRSA clones are accumulating in Japan. ? 2010 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
Subjects
Cellulitis; Child; Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA); Panton-Valentine leucocidin (PVL)
SDGs
Other Subjects
agr1 protein; agr1a protein; ampicillin; bacterial protein; biapenem; cefazolin; cefdinir; cefotaxime; cefotiam; cefoxitin; cefpirome; flomoxef; gentamicin; habekacin; imipenem; kanamycin; latamoxef; linezolid; macrolide; mec protein; meropenem; oxacillin; panipenem; Panton Valentine leukocidin; quinoline derived antiinfective agent; seb1 protein; streptomycin; teicoplanin; unclassified drug; unindexed drug; vancomycin; abdomen; antibiotic sensitivity; article; bacterium isolation; case report; cellulitis; child; clone; gene cassette; genotype; human; Japanese; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; multidrug resistance; nonhuman; nucleotide sequence; school child; Taiwan
Type
journal article