CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy
Journal
Cells
Journal Volume
9
Journal Issue
6
Date Issued
2020
Author(s)
Fu, Ssu-Ju
Peng, Yi-Jheng
Fang, Hsin-Yu
Hsiao, Cheng-Tsung
Chen, Tsung-Yu
Jeng, Chung-Jiuan
SDGs
Other Subjects
chloride channel; ClC-2 chloride channels; CRBN protein, human; Crbn protein, mouse; CUL4A protein, human; CUL4B protein, human; cullin; DDB1 protein, human; DNA binding protein; polyubiquitin; signal transducing adaptor protein; ubiquitin protein ligase; animal; biological model; brain disease; C57BL mouse; enzyme specificity; HEK293 cell line; human; hyperaldosteronism; metabolism; pathology; protein degradation; protein homeostasis; ubiquitination; Wistar rat; Adaptor Proteins, Signal Transducing; Animals; Brain Diseases; Chloride Channels; Cullin Proteins; DNA-Binding Proteins; HEK293 Cells; Humans; Hyperaldosteronism; Mice, Inbred C57BL; Models, Biological; Polyubiquitin; Proteolysis; Proteostasis; Rats, Wistar; Substrate Specificity; Ubiquitin-Protein Ligases; Ubiquitination
Publisher
NLM (Medline)
Type
journal article