Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis
Journal
Molecular and Cellular Oncology
Journal Volume
3
Journal Issue
1
Pages
e1029064
Date Issued
2016
Author(s)
Abstract
Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer. ? 2016, ? 2016 Taylor & Francis Group, LLC.
SDGs
Publisher
Taylor and Francis Ltd.
Type
journal article