https://scholars.lib.ntu.edu.tw/handle/123456789/507616
標題: | Upregulated interleukin-21 receptor on B cells associated with the downregulation of ige in patients with allergic rhinitis | 作者: | Jen H.-Y. YAO-HSU YANG BOR-LUEN CHIANG YA-HUI CHUANG |
公開日期: | 2015 | 卷: | 35 | 期: | 1 | 起(迄)頁: | 42-48 | 來源出版物: | Journal of Interferon and Cytokine Research | 摘要: | Allergic diseases, such as allergic rhinitis, caused by an immunoglobulin E (IgE)-mediated reaction to specific allergens are a common chronic condition worldwide. Interleukin-21 (IL-21), a type I cytokine that is produced by T cells, exerts regulatory effects on a variety of immune cells. In our previous study, we found that serum levels of IL-21 were significantly decreased in patients with severe atopic dermatitis, suggesting that IL-21 might play a role in allergic reactions. In this study, we investigated the role of IL-21/IL-21 receptor (IL-21R) in patients with allergic rhinitis. Our results demonstrated that there was no difference in IL-21 serum levels between allergic rhinitis patients and controls. However, allergic patients had significantly increased expression of IL-21R on naive and memory B cells. IL-21R was upregulated through stimulation by the combination of CD40 ligand (CD40L) and IL-4. IL-21 alone neither induced nor inhibited IgE secretion from CD40L-stimulated B cells. However, IL-21 inhibited IgE secretion of B cells that were induced by the combination of CD40L and IL-4 in allergic patients. Moreover, a negative correlation between the expression of IL-21R and serum levels of IgE was found in patients with allergy. These results suggest that the role of IL-21 in an ongoing allergic reaction is to downregulate the IgE level by binding to IL-21R on B cells, which increases the expression in allergic patients. ? 2015, Mary Ann Liebert, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/507616 | ISSN: | 1079-9907 | DOI: | 10.1089/jir.2014.0036 | SDG/關鍵字: | CD40 ligand; immunoglobulin E; immunoglobulin E antibody; interleukin 21 receptor; recombinant interleukin 21; recombinant interleukin 4; amino acid oxidase; IL21R protein, human; IL4I1 protein, human; immunoglobulin E; interleukin 21; interleukin 21 receptor alpha; interleukin derivative; protein binding; adult; allergic rhinitis; Article; B lymphocyte; blood level; blood sampling; chronic rhinitis; clinical article; controlled study; ELISA kit; female; human; human cell; immunoglobulin production; male; memory cell; peripheral blood mononuclear cell; priority journal; allergic rhinitis; B lymphocyte; biosynthesis; blood; down regulation; immunology; metabolism; upregulation; young adult; Adult; B-Lymphocytes; CD40 Ligand; Down-Regulation; Female; Humans; Immunoglobulin E; Interleukin-21 Receptor alpha Subunit; Interleukins; L-Amino Acid Oxidase; Male; Protein Binding; Rhinitis, Allergic; Up-Regulation; Young Adult |
顯示於: | 醫學檢驗暨生物技術學系 |
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