https://scholars.lib.ntu.edu.tw/handle/123456789/507665
標題: | When fats commit crimes: Fatty acid metabolism, cancer stemness and therapeutic resistance | 作者: | CHING-YING KUO Ann D.K. |
關鍵字: | Cancer cell plasticity; Cancer stem cells; Drug-tolerant persisters; Fatty acid metabolism; Fatty acid oxidation; Fatty acid synthesis; Lipogenic phenotype; Therapeutic resistance; Tumor-initiating cells | 公開日期: | 2018 | 卷: | 38 | 期: | 1 | 起(迄)頁: | 47 | 來源出版物: | Cancer Communications | 摘要: | The role of fatty acid metabolism, including both anabolic and catabolic reactions in cancer has gained increasing attention in recent years. Many studies have shown that aberrant expression of the genes involved in fatty acid synthesis or fatty acid oxidation correlate with malignant phenotypes including metastasis, therapeutic resistance and relapse. Such phenotypes are also strongly associated with the presence of a small percentage of unique cells among the total tumor cell population. This distinct group of cells may have the ability to self-renew and propagate or may be able to develop resistance to cancer therapies independent of genetic alterations. Therefore, these cells are referred to as cancer stem cells/tumor-initiating cells/drug-tolerant persisters, which are often refractory to cancer treatment and difficult to target. Moreover, interconversion between cancer cells and cancer stem cells/tumor-initiating cells/drug-tolerant persisters may occur and makes treatment even more challenging. This review highlights recent findings on the relationship between fatty acid metabolism, cancer stemness and therapeutic resistance and prompts discussion about the potential mechanisms by which fatty acid metabolism regulates the fate of cancer cells and therapeutic resistance. ? 2018 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/507665 | ISSN: | 2523-3548 | DOI: | 10.1186/s40880-018-0317-9 | SDG/關鍵字: | acetyl coenzyme A; acetyl coenzyme A carboxylase; adenosine triphosphate citrate synthase; carnitine palmitoyltransferase I; cerulenin; enzalutamide; epidermal growth factor receptor 2; etomoxir; fatty acid synthase; isocitrate dehydrogenase; leptin; lipidome; liver X receptor; perhexiline; pyruvate dehydrogenase; pyruvate dehydrogenase kinase; Smad2 protein; STAT3 protein; transforming growth factor beta; antineoplastic antimetabolite; fatty acid; acetylation; cancer growth; cancer resistance; cancer stem cell; carboxylation; chromatin; chromatin assembly and disassembly; citric acid cycle; epithelial mesenchymal transition; fatty acid metabolism; fatty acid oxidation; gene expression; glioma stem cell; glycolysis; histone acetylation; human; leukemia; lipogenesis; malignant neoplasm; metabolic stress; mTOR signaling; pinocytosis; protein acetylation; protein expression; protein phosphorylation; Review; tumor growth; tumor microenvironment; ubiquitination; animal; drug effect; drug resistance; gene expression regulation; genetics; lipid metabolism; metabolism; neoplasm; Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fatty Acids; Gene Expression Regulation, Neoplastic; Humans; Lipid Metabolism; Neoplasms; Neoplastic Stem Cells |
顯示於: | 醫學檢驗暨生物技術學系 |
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