https://scholars.lib.ntu.edu.tw/handle/123456789/508042
標題: | Childhood severe acute respiratory syndrome in Taiwan and how to differentiate it from childhood influenza infection | 作者: | LUAN-YIN CHANG Huang F.-Y. Wu Y.-C. Su I.-J. Chiu N.-C. Chen K.-T. Wu H.-S. Lin T.-H. STEVEN SHINN-FORNG PENG CHUAN-LIANG KAO Lee C.-Y. LI-MIN HUANG |
公開日期: | 2004 | 卷: | 158 | 期: | 11 | 起(迄)頁: | 1037-1042 | 來源出版物: | Archives of Pediatrics and Adolescent Medicine | 摘要: | Objective: To investigate clinical features and outcomes of children in Taiwan with laboratory-confirmed severe acute respiratory syndrome (SARS) vs those of children with influenza to differentiate the 2 diseases. Design, Setting, and Participants: Patients 20 years or younger with clinical, epidemiological, and laboratory evidence of SARS from March to July 2003 vs children with virus culture-confirmed influenza in a 1:1 age- and sex-matched control group. Main Outcome Measures: Rates of symptoms, abnormal laboratory data, and outcomes of recovery, sequelae, or death. Results: The 15 SARS patients (9 girls and 6 boys) had a median age of 17 years (age range, 4-20 years). Nine patients (60%) were infected through household contact, 4 (27%) nosocomially, 1 (7%) through contact with a neighbor, and 1 (7%) after returning from Hong Kong. All 15 patients had fever, 3 (20%) had chills, and 11 (73%) had cough. Only 1 patient (7%) had sputum production; 1 (7%) had rhinorrhea. At presentation, 5 patients (33%) had leukopenia, 6 (40%) had lymphopenia, and 5 (33%) had monocytopenia. All children recovered without sequelae. Children with SARS had significantly lower incidences of rhinorrhea (odds ratio [OR], 0.01; 95% confidence interval [CI], 0.00-0.09), sputum production (OR, 0.10; 95% CI, 0.02-0.63), and sore throat (OR, 0.17; 95% CI, 0.03-0.85) than children with influenza. Both groups had similar incidences of leukopenia or lymphopenia, but SARS patients had a significantly higher incidence of monocytopenia (33% vs 0%, P = .04). Conclusions: Childhood SARS is usually not fatal. The absence of rhinorrhea and presence of monocytopenia in SARS may distinguish it from influenza. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508042 | ISSN: | 1072-4710 | DOI: | 10.1001/archpedi.158.11.1037 | SDG/關鍵字: | adolescent; adult; article; child; childhood disease; chill; clinical article; clinical feature; controlled study; convalescence; coughing; disease transmission; female; fever; Hong Kong; hospital infection; household; human; influenza; leukopenia; lymphocytopenia; male; monocyte; monocytopenia; priority journal; rhinorrhea; severe acute respiratory syndrome; sore throat; sputum; Taiwan; travel; Adolescent; Adult; Anti-Bacterial Agents; Child; Child, Preschool; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Influenza, Human; Male; Reverse Transcriptase Polymerase Chain Reaction; Severe Acute Respiratory Syndrome; Taiwan |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。