https://scholars.lib.ntu.edu.tw/handle/123456789/508236
標題: | Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease | 作者: | CHIN-CHUNG SHU Wu M.-F. Lee C.-H. JANN-TAY WANG JANN-YUAN WANG CHONG-JEN YU LI-NA LEE PAN-CHYR YANG Su W.-J. HSIN-CHIH LAI VIN-CENT WU Yu M.-C. |
公開日期: | 2011 | 卷: | 15 | 期: | 10 | 起(迄)頁: | 1415-1420 | 來源出版物: | International Journal of Tuberculosis and Lung Disease | 摘要: | BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ?65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD. ? 2011 The Union. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/508236 | ISSN: | 1027-3719 | DOI: | 10.5588/ijtld.10.0786 | SDG/關鍵字: | C reactive protein; gamma interferon; procalcitonin; triggering receptor expressed on myeloid cells 1; adult; aged; area under the curve; article; bacterial colonization; bone marrow cell; cause of death; controlled study; disease association; female; human; lung disease; major clinical study; male; molecular diagnosis; mortality; Mycobacterium intracellulare avium; Mycobacterium kansasii; non tuberculous mycobacterial lung disease; prediction; priority journal; prognosis; protein expression; protein function; receiver operating characteristic; risk assessment; risk factor; sensitivity and specificity; sputum smear; survival time; Aged; Aged, 80 and over; Biological Markers; C-Reactive Protein; Calcitonin; Chi-Square Distribution; Humans; Interferon-gamma; Kaplan-Meier Estimate; Logistic Models; Lung Diseases; Membrane Glycoproteins; Middle Aged; Multivariate Analysis; Mycobacterium avium; Mycobacterium Infections, Nontuberculous; Mycobacterium kansasii; Prognosis; Proportional Hazards Models; Prospective Studies; Protein Precursors; Receptors, Immunologic; Risk Assessment; Risk Factors; Sensitivity and Specificity; Sputum; Taiwan; Up-Regulation |
顯示於: | 醫學檢驗暨生物技術學系 |
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