Behavioural phenotyping of dopamine transporter knockdown mice using local small interference RNA
Journal
Behavioural Brain Research
Journal Volume
214
Journal Issue
2
Pages
475-479
Date Issued
2010
Author(s)
Chen, Y.-C.
Abstract
The objective of this study was to evaluate basic behavioural phenotypes and methamphetamine-induced hyperactivity in dopamine transporter (DAT) knockdown and control mice after local injections of small interference RNA into ventral tegmental area/substantia nigra once every other day for 14 days. Local knockdown of DAT expression in the mouse brain did not affect basic behavioural functions, but these mice displayed elevated depression-like immobility and a approximately 35% reduction of methamphetamine-induced hyperactivity.
SDGs
Type
journal article