https://scholars.lib.ntu.edu.tw/handle/123456789/510023
標題: | Antivirals and vaccines for Enterovirus A71 | 作者: | JING-YI LIN Kung Y.-A. Shih S.-R. |
關鍵字: | Antivirals; Enterovirus A71; Vaccines | 公開日期: | 2019 | 卷: | 26 | 期: | 1 | 起(迄)頁: | 65 | 來源出版物: | Journal of Biomedical Science | 摘要: | Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or severe neurological complications. However, there are still no effective antivirals for treatment of these infections. In this review, we summarize the antiviral compounds developed to date based on various targets of the EV-A71 life cycle. Moreover, development of a vaccine would be the most effective approach to prevent EV-A71 infection. Therefore, we also summarize the development and clinical progress of various candidate EV-A71 vaccines, including inactivated whole virus, recombinant VP1 protein, synthetic peptides, viral-like particles, and live attenuated vaccines. ? 2019 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510023 | ISSN: | 1021-7770 | DOI: | 10.1186/s12929-019-0560-7 | SDG/關鍵字: | antivirus agent; virus vaccine; animal; Enterovirus A; Enterovirus infection; human; immunology; mouse; Animals; Antiviral Agents; Enterovirus A, Human; Enterovirus Infections; Humans; Mice; Viral Vaccines |
顯示於: | 醫學檢驗暨生物技術學系 |
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