High serum levels of procalcitonin and soluble TREM-1 correlated with poor prognosis in pulmonary tuberculosis
Journal
Journal of Infection
Journal Volume
68
Journal Issue
5
Pages
440-447
Date Issued
2014
Author(s)
Abstract
Objectives: Comparisons of procalcitonin (PCT), C-reactive protein (CRP), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) would expand our knowledge of which biomarker is the best predictor for outcomes of patients with pulmonary tuberculosis (PTB). Methods: We prospectively enrolled 243 PTB patients, in whom PCT, CRP, and sTREM-1 measurement were performed to evaluate their prognostic value for 6-month mortality. Results: Serum PCT, CRP, and sTREM-1 levels on diagnosis of PTB were significantly higher in nonsurvivors (2.22±6.22 vs. 0.13±0.31ng/mL, P=0.043; 42.1±59.4 vs. 12.5±29.1mg/L, P=0.004; 332±362 vs. 128±98pg/mL, P=0.001, respectively) as compared with 6-month survivors. In multivariate Cox regression analysis, PCT ≧0.5ng/mL (hazard ratio 4.13, 95% CI, 1.99-8.58) and sTREM-1 ≧129pg/mL (hazard ratio 3.39, 95% CI, 1.52-7.58) remained independent mortality predictors. Serum PCT and sTREM-1 levels above the cutoffs were also associated with the presence of disseminated tuberculosis. Conclusions: Among PTB patients, higher PCT, CRP, and sTREM-1 levels are observed in nonsurvivors than in 6-month survivors. Serum levels of PCT and sTREM-1 over the cutoffs are independently associated with a poor outcome. In addition, higher PCT and sTREM-1 levels would raise the clinical suspicion of disseminated tuberculosis. ? 2014 The Authors.
SDGs
Other Subjects
biological marker; C reactive protein; procalcitonin; triggering receptor expressed on myeloid cells 1; C reactive protein; calcitonin; immunoglobulin receptor; membrane protein; procalcitonin; protein precursor; TREM1 protein, human; adult; area under the curve; article; clinical evaluation; controlled study; diagnostic test accuracy study; disease association; female; human; lung tuberculosis; major clinical study; male; miliary tuberculosis; mortality; outcome assessment; pleura effusion; predictive value; prognosis; prospective study; protein blood level; protein expression; receiver operating characteristic; sensitivity analysis; aged; blood; chemistry; middle aged; pathology; prognosis; serum; survival; Tuberculosis, Pulmonary; very elderly; young adult; Adult; Aged; Aged, 80 and over; C-Reactive Protein; Calcitonin; Female; Humans; Male; Membrane Glycoproteins; Middle Aged; Prognosis; Prospective Studies; Protein Precursors; Receptors, Immunologic; Serum; Survival Analysis; Tuberculosis, Pulmonary; Young Adult
Publisher
W.B. Saunders Ltd
Type
journal article