https://scholars.lib.ntu.edu.tw/handle/123456789/510569
標題: | Dialysis membranes influence perfluorochemical concentrations and liver function in patients on hemodialysis | 作者: | Yen-Ting Lai Liu, Wen-Sheng ; Chan, Hsiang Lin ; Lin, Chih-Ching ; Li, Szu-Yuan ; Liu, Chih-Kuang ; Tsou, Han-Hsing ; Liu, Tsung-Yun |
關鍵字: | Dialysis membrane; Hemodialysis; LC-MS/MS; Perfluorochemicals; Polysulfone | 公開日期: | 2018 | 卷: | 15 | 期: | 11 | 起(迄)頁: | 2574 | 來源出版物: | International journal of environmental research and public health | 摘要: | Introduction: Perfluoro-octanesulfonate (PFOS) and perfluoro-octanoic acid (PFOA) are two toxic perfluorochemicals (PFCs) commonly used as surfactants. PFCs are difficult to be eliminated from the body. We investigated the influence of different dialysis membranes on the concentrations of PFCs in patients under hemodialysis. Method: We enrolled 98 patients. Of these, 58 patients used hydrophobic polysulfone (PS) dialysis membranes, and the other 40 had hydrophilic membranes made by poly-methyl methacrylate (PMMA) or cellulose triacetate (CTA). Liquid chromatography tandem mass spectrometry coupled was used with isotope dilution to quantify PFOA and PFOS. Results: The predialysis concentrations of PFOA and PFOS in patients with hydrophobic PS dialysis membranes were 0.50 and 15.77 ng/mL, respectively, lower than the concentrations of 0.81 and 22.70 ng/mL, respectively, in those who used hydrophilic membranes (such as CTA or PMMA). Older patients have higher PFOS and poorer body function, with lower Karnofsky Performance Status Scale (KPSS) scores. The demographic data of the two groups were similar. However, patients with hydrophobic PS dialysis membranes had lower predialysis aspartate transaminase (AST) (p = 0.036), lower glucose levels (p = 0.017), and better body function (nonsignificantly higher KPSS scores, p = 0.091) compared with patients who used other membranes. These differences may be associated with the effects of different membranes, because PFOA positively correlated with AST, while PFOS negatively correlated with body function. Conclusions: This is the first study comparing PFC levels in uremic patients with different dialysis membrane. PS membrane may provide better clearance of PFCs and may, therefore, be beneficial for patients. ? 2018, MDPI AG. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056691875&doi=10.3390%2fijerph15112574&partnerID=40&md5=15e4d6f9ced04053167bec124fc2289c https://scholars.lib.ntu.edu.tw/handle/123456789/510569 |
DOI: | 10.3390/ijerph15112574 | SDG/關鍵字: | albumin; alkaline phosphatase; aluminum; aspartate aminotransferase; bilirubin; calcium; cellulose triacetate; cholesterol; creatinine; ferritin; globulin; glucose; hemoglobin; parathyroid hormone; perfluoro compound; perfluorooctanesulfonic acid; perfluorooctanoic acid; phosphorus; poly(methyl methacrylate); polysulfone; protein; sodium; surfactant; triacylglycerol; uric acid; aspartate aminotransferase; fluorocarbon; adult; Article; blood flow; cross-sectional study; diabetes mellitus; drug blood level; electrospray; female; glucose level; hematocrit; hemodialysis; hepatitis; human; hydrophilicity; hydrophobicity; hypertension; iron binding capacity; iron therapy; isotope dilution assay; Karnofsky Performance Status; liquid chromatography-mass spectrometry; liver function; major clinical study; male; mean corpuscular volume; middle aged; uremia; age; aged; artificial membrane; blood; chemical phenomena; chemistry; glucose blood level; health status; hemodialysis; liquid chromatography; liver; metabolism; procedures; Adult; Age Factors; Aged; Aspartate Aminotransferases; Blood Glucose; Chromatography, Liquid; Cross-Sectional Studies; Female; Fluorocarbons; Health Status; Humans; Hydrophobic and Hydrophilic Interactions; Liver; Male; Membranes, Artificial; Middle Aged; Renal Dialysis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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