https://scholars.lib.ntu.edu.tw/handle/123456789/510893
標題: | Circulating Diabetic Candidate Neurotrophic Factors, Brain-Derived Neurotrophic Factor and Fibroblast Growth Factor 21, in Sleeve Gastrectomy | 作者: | HUNG-HSUAN YEN SUNG-TSANG HSIEH CHI-LING CHEN WEI-SHIUNG YANG PO-CHU LEE MING-TSAN LIN CHIUNG-NIEN CHEN PO-JEN YANG |
公開日期: | 1-十二月-2020 | 卷: | 10 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | © 2020, The Author(s). Recent studies show brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 21 (FGF21) are neurotrophic factors associated with obesity and diabetes mellitus (DM). Laparoscopic sleeve gastrectomy (LSG) can significantly reduce weight and improve DM. In this study, we enrolled 78 patients with obesity and evaluated the change of BDNF and FGF21 6 months after LSG. At baseline, the BDNF level was similar between the preoperative DM (n = 30) (17.1 ± 7.7 ng/ml) and non-DM (n = 48) (17.0 ± 6.9 ng/ml) patients with obesity, but FGF21 was significantly higher in the DM patients (201.5 ± 204.3 versus 107.6 ± 63.8 pg/ml). At 6 months after LSG, most of the preoperative DM patients (96.7%) had DM either resolved (66.7%) or improved (30%). BDNF increased and FGF21 decreased significantly regardless of the preoperative DM status, while FGF21 decreased more prominently in the preoperative DM patients (−92.6 ± 179.8 versus −4.6 ± 63.4 pg/ml). After adjusted for age, sex, and preoperative DM status, FGF21 became significantly and positively related to C-peptide (β = 18.887), insulin (β = 2.399), and homeostasis model assessment of insulin resistance index (β = 8.566) after surgery. In conclusion, diabetic patients with obesity had higher FGF21 and similar BDNF levels compared to non-diabetic obese patients. BDNF increased and FGF21 decreased significantly after LSG. FGF21 became positively associated with several insulin-related profiles after surgery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/510893 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-62395-z | SDG/關鍵字: | BDNF protein, human; biological marker; brain derived neurotrophic factor; FGF21 protein, human; fibroblast growth factor; insulin; adult; blood; female; gastrectomy; human; laparoscopy; male; middle aged; morbid obesity; non insulin dependent diabetes mellitus; procedures; prospective study; Adult; Biomarkers; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Type 2; Female; Fibroblast Growth Factors; Gastrectomy; Humans; Insulin; Laparoscopy; Male; Middle Aged; Obesity, Morbid; Prospective Studies |
顯示於: | 解剖學暨細胞生物學科所 |
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