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  3. Clinical Laboratory Sciences and Medical Biotechnology / 醫學檢驗暨生物技術學系所
  4. Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults
 
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Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults

Journal
International Journal of Cardiology
Journal Volume
168
Journal Issue
4
Pages
3309-3316
Date Issued
2013
Author(s)
Lin C.-Y.
LIAN-YU LIN  
Wen T.-W.
Lien G.-W.
KUO-LIONG CHIEN  
SANDY HUEY-JEN HSU  
Liao C.-C.
Sung F.-C.
PAU-CHUNG CHEN  
TA-CHEN SU  
DOI
10.1016/j.ijcard.2013.04.042
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/510925
Abstract
Background Perfluorinated chemicals (PFCs) have been widely used for years in a variety of products worldwide. Although epidemiological findings have shown that PFC levels are positively associated with cholesterol and uric acid levels, it is unknown whether PFCs are associated with atherosclerosis. Methods We recruited 664 subjects (12-30 years) from a population-based sample of adolescents and young adults based on a mass urine screening to determine the relationship between serum levels of PFCs and carotid intima-media thickness (CIMT). Results The median concentrations and ranges of perfluorooctanoic acid (PFOA), perfluorooctane sulfate (PFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFUA) were 3.49 (0.75-52.2) ng/mL, 8.65 (0.11-85.90) ng/mL, 0.38 (0.38-25.4) ng/mL, and 6.59 (1.50-105.7) ng/mL, respectively. After controlling for age, gender, smoking status, systolic blood pressure, body mass index, low-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance, multiple linear regression analysis revealed that CIMT increased significantly across quartiles of PFOS (0.434 mm, 0.446 mm, 0.458 mm, 0.451 mm; P for trend < 0.001). Subpopulation analysis showed the association between PFOS and CIMT was more evident and significant in females, non-smokers, subjects of age 12-19 years, BMI < 24, and those with APOE genotype of E2 carrier and E3/E3. Conclusions Higher serum concentrations of PFOS were associated with an increase of carotid IMT in this cohort of adolescents and young adults. Further studies are warranted to clarify the causal relationship between PFOS and atherosclerosis. ? 2013 Elsevier Ireland Ltd.
SDGs

[SDGs]SDG3

Other Subjects
apolipoprotein E2; apolipoprotein E3; C reactive protein; insulin; low density lipoprotein cholesterol; perfluoro compound; perfluorodecanoic acid; perfluorononanoic acid; perfluorooctane sulfate; perfluorooctanoic acid; triacylglycerol; unclassified drug; uric acid; adolescent; adult; age distribution; arterial wall thickness; article; atherosclerosis; blood level; body mass; child; cholesterol blood level; cross-sectional study; disease marker; female; genotype; human; insulin resistance; major clinical study; male; priority journal; risk factor; school child; sex difference; smoking; systolic blood pressure; triacylglycerol blood level; uric acid blood level; Carotid intima-media thickness; Perfluorinated chemicals; Perfluorononanoic acid; Perfluorooctane sulfate; Adolescent; Adult; Alkanesulfonic Acids; Biological Markers; Carotid Intima-Media Thickness; Child; Cohort Studies; Cross-Sectional Studies; Female; Fluorocarbons; Follow-Up Studies; Humans; Male; Young Adult
Type
journal article

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