Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. National Taiwan University Hospital / 醫學院附設醫院 (臺大醫院)
  4. Proton MR spectroscopy of normal breasts: Association of risk factors for breast cancer with water and lipid composition of the breast
 
  • Details

Proton MR spectroscopy of normal breasts: Association of risk factors for breast cancer with water and lipid composition of the breast

Journal
Magnetic Resonance Imaging
Journal Volume
34
Journal Issue
4
Pages
524-528
Date Issued
2016
Author(s)
JANE WANG  
Wang M.-Y.
WEN-HUNG KUO  
Chen K.-L.
TIFFANY TING-FANG SHIH  
DOI
10.1016/j.mri.2015.12.028
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/511174
Abstract
Purpose: To investigate the water and lipid composition of normal women breasts on proton MR spectroscopy (1H-MRS), and the association of breast cancer risk factors with 1H-MRS parameters. Materials and methods: Three groups of participants were included: group 1, women without a family history of breast cancer (n = 49); group 2, women with at least one affected first-degree relative (n = 77); group 3, contralateral normal breasts of women with newly diagnosed unilateral breast cancer (n = 84). 1H-MRS parameters were shown below: water fraction 1 (WF1) = (water integral)/(water integral + integral for methylene peak); lipid line width for methylene resonance (LW1) and lipid line width for methyl peaks (LW2) were measured. The association of breast cancer risk factors - age, breast density, body mass index (BMI), menopausal status, group with 1H-MRS parameters - was analyzed by multiple linear regression. Results: In age-adjusted multiple linear regression, breast density was positively associated with WF1 (P = 0.009, 0.001, and < 0.001 for groups 1, 2, and 3, respectively). BMI was inversely associated with LW1 in groups 1 (P = 0.040) and 3 (P = 0.005). In group 3, premenopausal breasts had lower LW2 than their postmenopausal counterparts (P = 0.033). Group 3 had narrower LW2 than group 2 (P = 0.007). Conclusions: The risk factors for breast cancer were associated with 1H-MRS parameters. ? 2015 Elsevier Inc.
SDGs

[SDGs]SDG3

Other Subjects
adult; age; Article; body mass; breast cancer; breast density; cancer risk; controlled study; family history; female; first degree relative; human; lipid composition; major clinical study; nuclear magnetic resonance scanner; postmenopause; premenopause; priority journal; prospective study; proton nuclear magnetic resonance; water content; adipose tissue; aged; breast; breast tumor; chemistry; diagnostic imaging; middle aged; risk factor; statistical model; lipid; water; Adipose Tissue; Adult; Aged; Breast; Breast Density; Breast Neoplasms; Female; Humans; Linear Models; Lipids; Middle Aged; Proton Magnetic Resonance Spectroscopy; Risk Factors; Water
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science