|Title:||Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress||Authors:||Lamonte, Gregory
Chen, Julia Ling-Yu
Ding, Chien-Kuang Cornelia
Keenan, Melissa M
Boros, László G
Newgard, Christopher B
|Issue Date:||23-Dec-2013||Journal Volume:||1||Journal Issue:||1||Source:||Cancer & metabolism||Abstract:||
A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microenvironmental stress in solid tumors, but little is known about its metabolic influence, particularly when present in the absence of hypoxia. In order to characterize the extent of tumor cell metabolic adaptations to acidosis, we employed stable isotope tracers to examine how acidosis impacts glucose, glutamine, and palmitate metabolism in breast cancer cells exposed to extracellular acidosis.
|Appears in Collections:||解剖學暨細胞生物學科所|
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