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  1. NTU Scholars
  2. 醫學院
  3. 醫學院附設醫院 (臺大醫院)
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/511311
Title: Incidence and Risk Factor Analysis of Thromboembolic Events in East Asian Patients with Inflammatory Bowel Disease, a Multinational Collaborative Study
Authors: Weng M.-T.
Park S.H.
Matsuoka K.
CHIEN-CHIH TUNG 
Lee J.Y.
Chang C.-H.
Yang S.-K.
Watanabe M.
Wong J.-M.
Wei S.-C.
Issue Date: 2018
Journal Volume: 24
Journal Issue: 9
Start page/Pages: 1791-1800
Source: Inflammatory Bowel Diseases
Abstract: 
Background Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism (VTE) events. However, the incidence and necessity of prophylaxis for VTE in Asian IBD patients is unknown. We examined the incidence of VTE in East Asian IBD patients and analyze the possible risk factors. Methods We conducted a multinational retrospective study of 2562 hospitalized IBD patients from 2010 to 2015. Moreover, a nationwide cohort study from 2001 to 2013 from the Taiwan National Health Insurance Research Database (NHIRD) was conducted to analyze the incidence rate of VTE in IBD and non-IBD patients. Results In the hospitalized cohort, 24 IBD patients [17 ulcerative colitis (UC) and 7 Crohn's disease (CD)] received a VTE diagnosis (0.9%). These patients had a higher proportion of extensive UC (P = 0.04), penetrating-type CD (P < 0.01), and bowel operation history (P = 0.01). VTE was associated with low hemoglobin (P < 0.01), low platelet (P < 0.01), and low albumin (P < 0.01) levels. For the nation-wide cohort study, 3178 IBD patients and 31,780 age- and sex-matched non-IBD patients were analyzed. The average incidence rate was 1.15 per 1000 person-years in the IBD cohort and 0.51 in the non-IBD cohort. The relative risk was 2.27 (95% CI, 1.99-2.60). Conclusions East Asian IBD patients carry a 2-fold increased risk of VTE than the general population. The incidence of VTE in the East Asian IBD patients is still lower than that in Western countries. Therefore, close monitoring rather than routine prophylaxis of VTE in East Asian IBD patients is recommended. ? 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved.
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/511311
ISSN: 1078-0998
DOI: 10.1093/ibd/izy058
metadata.dc.subject.other: albumin; hemoglobin; adolescent; adult; age; age distribution; aged; Article; child; cohort analysis; controlled study; Crohn disease; disease association; East Asian; female; gender; hospital patient; human; incidence; inflammatory bowel disease; major clinical study; male; middle aged; patient history of surgery; priority journal; retrospective study; risk assessment; risk factor; sex ratio; smoking; thrombocyte; thromboembolism; ulcerative colitis; very elderly; clinical trial; complication; factor analysis; Far East; incidence; infant; inflammatory bowel disease; multicenter study; preschool child; regression analysis; risk factor; venous thromboembolism; young adult; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Child; Child, Preschool; Factor Analysis, Statistical; Far East; Female; Humans; Incidence; Infant; Inflammatory Bowel Diseases; Male; Middle Aged; Regression Analysis; Retrospective Studies; Risk Factors; Sex Distribution; Venous Thromboembolism; Young Adult
[SDGs]SDG3
Appears in Collections:醫學院附設醫院 (臺大醫院)

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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