|Title:||Hes1 increases the invasion ability of colorectal cancer cells via the STAT3-MMP14 pathway||Authors:||Weng M.T.
|Issue Date:||2015||Journal Volume:||10||Journal Issue:||12||Start page/Pages:||144322||Source:||PLoS ONE||Abstract:||
The Notch pathway contributes to self-renewal of tumor-initiating cell and inhibition of normal colonic epithelial cell differentiation. Deregulated expression of Notch1 and Jagged1 is observed in colorectal cancer. Hairy/enhancer of split (HES) family, the most characterized targets of Notch, involved in the development of many cancers. In this study, we explored the role of Hes1 in the tumorigenesis of colorectal cancer. Knocking down Hes1 induced CRC cell senescence and decreased the invasion ability, whereas over-expression of Hes1 increased STAT3 phosphorylation activity and up-regulated MMP14 protein level. We further explored the expression of Hes1 in human colorectal cancer and found high Hes1 mRNA expression is associated with poor prognosis in CRC patients. These findings suggest that Hes1 regulates the invasion ability through the STAT3-MMP14 pathway in CRC cells and high Hes1 expression is a predictor of poor prognosis of CRC. ? 2015 Weng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/511318||ISSN:||1932-6203||DOI:||10.1371/journal.pone.0144322||metadata.dc.subject.other:||matrix metalloproteinase 14; messenger RNA; STAT3 protein; transcription factor HES 1; HES1 protein, human; matrix metalloproteinase 14; MMP14 protein, human; STAT3 protein; STAT3 protein, human; transcription factor HES 1; adult; aged; Article; cancer prognosis; cancer staging; cell aging; cell viability; cohort analysis; colon carcinogenesis; colorectal cancer; colorectal cancer cell line; controlled study; female; human; human cell; human tissue; in vitro study; male; protein expression; protein phosphorylation; senescence; signal transduction; tumor invasion; upregulation; colorectal tumor; genetics; metabolism; pathology; phosphorylation; physiology; signal transduction; tumor invasion; Cellular Senescence; Colorectal Neoplasms; Humans; Matrix Metalloproteinase 14; Neoplasm Invasiveness; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Transcription Factor HES-1; Up-Regulation
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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