Autoimmune pancreatitis associated with high prevalence of gastric ulcer independent of Helicobacter pylori infection status
Journal
Pancreas
Journal Volume
38
Journal Issue
4
Pages
442-446
Date Issued
2009
Author(s)
Abstract
OBJECTIVES: The relationship between Helicobacter pylori status and host tumor necrosis factor α (TNF-α) promoter susceptibility in ulcers inautoimmune pancreatitis (AIP) is unknown. We sought to study the frequency of peptic ulcer, the association of peptic ulcer with H. pylori and host TNF-α promoter haplotype in AIP and nonautoimmune chronic pancreatitis. METHODS: Esophagogastroduodenoscopy (EGD) was performed in 40 patients with AIP and 113 patients with nonautoimmune chronic pancreatitis (CP). The status of H. pylori infection was determined. Genotyping and 5-locus haplotype assembly of the TNF-α promoter were performed. The correlation between clinical characteristics, endoscopic findings, Helicobacter pylori infection status, and TNF-α promoter polymorphism and haplotype was analyzed. RESULTS: The frequencies of gastric ulcer (GU) was higher in patients with AIP compared with patients with nonautoimmune CP (22.5% vs 4.4%, P = 0.001). Duodenal ulcer (DU) was more prevalent than GU in both patients with AIP and patients with nonautoimmune CP. There was no difference in the positive status of H. pylori and TNF-α promoter polymorphism/haplotype. CONCLUSIONS: Our results demonstrated that GU was more prevalent in AIP compared with nonautoimmune CP. Positive H. pylori status and host TNF-α promoter susceptibility could not explain the pathogenesis of higher GU prevalence and pathogenesis of AIP in our population. ? 2009 Lippincott Williams & Wilkins, Inc.
SDGs
Other Subjects
genomic DNA; immunoglobulin G antibody; tumor necrosis factor alpha; immunoglobulin G; tumor necrosis factor alpha; adult; aged; article; autoimmune pancreatitis; Chinese; clinical article; controlled study; correlation analysis; DNA polymorphism; duodenum ulcer; enzyme immunoassay; esophagogastroduodenoscopy; female; gene frequency; genotype; haplotype; Helicobacter infection; Helicobacter pylori; host susceptibility; human; human tissue; male; peptic ulcer; prevalence; priority journal; promoter region; stomach biopsy; stomach ulcer; autoimmune disease; digestive tract endoscopy; duodenum ulcer; genetic polymorphism; genetics; Helicobacter infection; host pathogen interaction; immunology; metabolism; microbiology; middle aged; nucleotide sequence; pancreas; pancreatitis; pathology; physiology; stomach ulcer; Adult; Aged; Autoimmune Diseases; Base Sequence; Duodenal Ulcer; Endoscopy, Digestive System; Female; Gene Frequency; Genotype; Haplotypes; Helicobacter Infections; Helicobacter pylori; Host-Pathogen Interactions; Humans; Immunoglobulin G; Male; Middle Aged; Pancreas; Pancreatitis; Polymorphism, Genetic; Promoter Regions, Genetic; Stomach Ulcer; Tumor Necrosis Factor-alpha
Type
journal article