https://scholars.lib.ntu.edu.tw/handle/123456789/511599
標題: | Inappropriate Peak Inspiratory Flow Rate with Dry Powder Inhaler in Chronic Obstructive Pulmonary Disease | 作者: | SHIH-YU CHEN CHUN-KAI HUANG Peng H.-C. CHONG-JEN YU JUNG-YIEN CHIEN |
公開日期: | 2020 | 出版社: | Nature Research | 卷: | 10 | 期: | 1 | 起(迄)頁: | 7271 | 來源出版物: | Scientific Reports | 摘要: | Optimal peak inspiratory flow rate (PIFR) is crucial for optimizing dry powder inhaler (DPI) effectiveness for chronic obstructive pulmonary disease (COPD). This study provide an insight that there was a substantial proportion of improper PIFRs (not only insufficient but also excessive) among COPD patients using DPIs. We enrolled 138 COPD patients from a medical center in Taiwan and measured PIFRs against different internal resistances of DPIs. Proportion of excessive, optimal, suboptimal, and insufficient PIFRs were 2%, 54%, 41%, 3%, respectively, against medium-high resistance; 2%, 77%, 20%, 1%, respectively, against medium resistance; 27%, 63%, 9%, 1%, respectively, against medium-low resistance; and 42%, 57%, 1%, 0%, respectively, against low resistance (p < 0.01). Although most PIFRs against medium-high (54%), medium (77%), medium-low (63%) and low (57%) resistance were optimal, a substantial proportion of PIFRs against low resistance were excessive (42%, p < 0.01), irrespective of age, body-mass index, dyspnea severity score, and COPD severity. Insufficient PIFRs were infrequent, but suboptimal/insufficient PIFRs were most prevalent in patients older than 75 years than in younger patients (36% vs. 56%, p = 0.036) against medium-high resistance. Regularly monitoring PIFRs against the specific resistance of the DPIs and instructing patients to employ a proper inspiration effort may help to optimize the effects of DPIs. ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083992620&doi=10.1038%2fs41598-020-64235-6&partnerID=40&md5=98fa5fe3969f357b36964e46646024d3 https://scholars.lib.ntu.edu.tw/handle/123456789/511599 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-64235-6 | SDG/關鍵字: | adult; adverse device effect; aged; airway resistance; chronic obstructive lung disease; dry powder inhaler; female; forced expiratory volume; human; inhalational drug administration; lung; male; middle aged; pathophysiology; Taiwan; very elderly; Administration, Inhalation; Adult; Aged; Aged, 80 and over; Airway Resistance; Dry Powder Inhalers; Female; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Taiwan |
顯示於: | 醫學系 |
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