Idiopathic pulmonary fibrosis
Journal
Journal of Internal Medicine of Taiwan
Journal Volume
29
Journal Issue
5
Pages
283-291
Date Issued
2018
Author(s)
Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic, and idiopathic interstitial pneumonia. It's prone to elderlies, and the disease involvement is confined to the lungs. There has a unique pathological findings called usual interstitial pneumonia (UIP) that can be found in both histology and images on computer tomography (CT). To make the diagnosis of IPF, all known-cause of interstitial lung diseases such as environmental factors, medications, connective tissue diseases should be excluded first. In the past, IPF is considered as a poorly prognostic disease, while the median survival time was 0.9 year in Taiwan. However, as the pathogenesis is being studied, anti-fibrotic drugs (nintedanib and pirfenidone) have been developed. They were proved to be effective to decrease lung function decline in some large-scale studies. Moreover, there are more ongoing studies among IPF trying to improve prognosis of IPF patients. ? 2018 Society of Internal Medicine of Taiwan. All rights reserved.
SDGs
Other Subjects
nintedanib; pirfenidone; Article; computer assisted tomography; disease course; environmental factor; fibrosing alveolitis; histology; human; internal medicine; interstitial pneumonia; lung fibrosis; lung function; median survival time; prognosis
Publisher
Society of Internal Medicine of Taiwan
Type
journal article