Estrogen replacement in female lung cancer during gefitinib therapy
Journal
Japanese Journal of Clinical Oncology
Journal Volume
39
Journal Issue
12
Pages
829-832
Date Issued
2009
Author(s)
Abstract
Estrogen receptor (ER) has been detected in some specimens of lung cancer. Estrogen has an effect on the growth of lung cancer cell lines. An inverse relationship between ER and epithelial growth factor receptor (EGFR) was reported in pre-clinical data. A 70-year-old female with lung adenocarcinoma, who achieved a partial response by gefitinib, underwent estrogen replacement for menopause-associated symptoms during gefinitib therapy. Lung nodules enlarged with 1-month estrogen use and regressed 6 weeks after the end of estrogen therapy. To our knowledge, this is the first case report regarding the interaction between estrogen and EGFR inhibitors. ? The Author (2009). Published by Oxford University Press. All rights reserved.
SDGs
Other Subjects
carcinoembryonic antigen; conjugated estrogen; epidermal growth factor receptor; estrogen receptor; gefitinib; thyroid transcription factor 1; aged; anamnesis; article; bronchoscopy; bronchus biopsy; cancer chemotherapy; cancer hormone therapy; case report; chest tightness; clinical feature; computer assisted tomography; drug efficacy; dyspnea; female; human; lung cancer; lung nodule; pleura effusion; thorax radiography; unspecified side effect; Animals; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Estrogen Replacement Therapy; Estrogens; Female; Humans; Lung Neoplasms; Quinazolines; Receptor, Epidermal Growth Factor
Type
journal article