https://scholars.lib.ntu.edu.tw/handle/123456789/512398
標題: | Predictors of radiographic progression for NTM–pulmonary disease diagnosed by bronchoscopy | 作者: | Huang H.-L. MENG-RUI LEE CHIA-JUNG LIU Cheng M.-H. Lu P.-L. JANN-YUAN WANG Chong I.-W. |
公開日期: | 2020 | 出版社: | W.B. Saunders Ltd | 卷: | 161 | 起(迄)頁: | 105847 | 來源出版物: | Respiratory Medicine | 摘要: | Objectives: A single isolate of nontuberculous mycobacterium (NTM) from bronchoscopic samples satisfies the microbiological criterion for diagnosing NTM-pulmonary disease (PD). Studies investigating patients with NTM-PD and multiple culture-negative sputum samples but culture-positive bronchoscopic samples are lacking. We investigated the clinical characteristics, outcome, and predictors of radiographic progression in this special population. Methods: Patients with negative NTM culture from ?2 expectorated sputum samples within the 3 months prior to bronchoscopy diagnosis of NTM-PD between 2009 and 2017 were included. Patient characteristics and clinical course were described. Predictors for radiographic progression of NTM-PD within 2 years were analysed by using multivariate logistic regression. Results: Among 66 patients with bronchoscopy-diagnosed NTM-PD, radiographic progression occurred within 2 years in 17 (26%). Of the 60 patients not initially treated, radiographic progression occurred in 17 (28%). Among them, 10 never received treatment, with 6 deteriorating and 3 dying. Of the 6 and 7 patients who received treatment immediately after NTM-PD diagnosis and after radiographic progression, respectively, none had further radiographic progression. The independent predictors of radiographic progression were male sex, body mass index <18.5 kg/m2, use of inhaled corticosteroids, and acid-fast smear grade ?2 of index bronchoscopic samples. Conclusions: Among patients with bronchoscopy-diagnosed NTM-PD, one fourth experienced radiographic progression within 2 years. The risk was even higher in those with the aforementioned predictors, immediate treatment or close monitoring is recommended. For others, conservative management by regular microbiological monitoring for sputum samples and image follow-up may be the optimal choice. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075499362&doi=10.1016%2fj.rmed.2019.105847&partnerID=40&md5=8a0f0ce31b3c3267d74185a46383dc3e https://scholars.lib.ntu.edu.tw/handle/123456789/512398 |
ISSN: | 0954-6111 | DOI: | 10.1016/j.rmed.2019.105847 | SDG/關鍵字: | antimycobacterial agent; corticosteroid; adult; aged; antimicrobial therapy; Article; atypical mycobacteriosis; atypical Mycobacterium; body mass; bronchoscopy; chronic kidney failure; cohort analysis; computer assisted tomography; corticosteroid therapy; disease course; disease exacerbation; drug use; female; human; lung disease; lung malformation; major clinical study; male; malnutrition; middle aged; Mycobacterium abscessus; Mycobacterium kansasii; nonhuman; priority journal; retrospective study; sex difference; sputum culture; thorax radiography; treatment outcome; atypical mycobacteriosis; diagnostic imaging; disease exacerbation; follow up; forecasting; outcome assessment; pathology; risk; time factor; very elderly; Aged; Aged, 80 and over; Bronchoscopy; Disease Progression; Female; Follow-Up Studies; Forecasting; Humans; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Patient Outcome Assessment; Retrospective Studies; Risk; Time Factors |
顯示於: | 醫學系 |
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