https://scholars.lib.ntu.edu.tw/handle/123456789/512412
標題: | Predictors of developing Mycobacterium kansasii pulmonary disease within 1 year among patients with single isolation in multiple sputum samples: A retrospective, longitudinal, multicentre study | 作者: | Huang H.-L. Cheng M.-H. Lu P.-L. CHIA-JUNG LIU Chong I.-W. JANN-YUAN WANG |
公開日期: | 2018 | 出版社: | Nature Publishing Group | 卷: | 8 | 期: | 1 | 起(迄)頁: | 17826 | 來源出版物: | Scientific Reports | 摘要: | The clinical significance of a single Mycobacterium kansasii (MK) isolation in multiple sputum samples remains unknown. We conducted this study to evaluate the outcome and predictors of developing MK-pulmonary disease (PD) within 1 year among these patients. Patients with a single MK isolation from ?3 sputum samples collected within 3 months and ?2 follow-up sputum samples and chest radiography in the subsequent 9 months between 2008 and 2016 were included. The primary outcome was development of MK-PD within 1 year, with its predictors explored using multivariate logistic regression analysis. A total of 83 cases of a single MK isolation were identified. The mean age was 68.9 ± 17.9, with a male/female ratio of 1.96. Within 1 year, 16 (19%) cases progressed to MK-PD; risk factors included high acid-fast smear (AFS) grade (?3), elementary occupation workers, and initial radiographic score >6, whereas coexistence with other nontuberculous mycobacterium species was protective. Among patients who developed MK-PD, all experienced radiographic progression, and 44% died within 1 year. Although a single MK isolation does not fulfil the diagnostic criteria of MK-PD, this disease may develop if having above-mentioned risk factors. Early anti-MK treatment should be considered for high-risk patients. ? 2018, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058612226&doi=10.1038%2fs41598-018-36255-w&partnerID=40&md5=7a3b89aad314598e84ecfce1bc3d81a7 https://scholars.lib.ntu.edu.tw/handle/123456789/512412 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-36255-w | SDG/關鍵字: | aged; atypical mycobacteriosis; clinical trial; diagnostic imaging; female; human; isolation and purification; longitudinal study; lung disease; male; microbiology; middle aged; mortality; multicenter study; Mycobacterium kansasii; retrospective study; risk factor; sputum; time factor; very elderly; Aged; Aged, 80 and over; Female; Humans; Longitudinal Studies; Lung Diseases; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Mycobacterium kansasii; Retrospective Studies; Risk Factors; Sputum; Time Factors |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。