Epidemiology and Predictors of NTM Pulmonary Infection in Taiwan - A Retrospective, Five-Year Multicenter Study
Journal
Scientific Reports
Journal Volume
7
Journal Issue
1
Pages
16300
Date Issued
2017
Author(s)
Abstract
Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance of each respiratory NTM isolate in six hospitals between 2008 and 2014 was determined according to current guidelines. Recurrent episodes were judged by serial bacteriological results. New episodes of NTM-PI and pulmonary colonization (PC) occurring since 2010 were analyzed. Logistic regression analysis was performed to identify the predictors of NTM-PI. Between 2010 and 2014, the incidence rate of NTM-PI was 46.0 episodes per 100,000 hospital-based patient-years. Mycobacterium avium intracellulare complex (MAC) was predominant in Northern Taiwan, whereas MAC and M. abscessus were copredominant in Southern Taiwan. Multiple episodes occurred in 9.5% of NTM-PI patients. No female predominance was observed, except for MAC-PI. Previous pulmonary tuberculosis and chronic obstructive pulmonary disease (COPD) were the most common pulmonary comorbidities and independent risk factors for NTM-PI. Other risk factors included M. kansasii, M. abscessus, and southern Taiwan. Geographical variation of NTM-PI exists in Taiwan. Clinicians should keep a high suspicion on NTM-PI in the risk population. In endemic area of tuberculosis and COPD, there may be no female predominance in NTM-PI. ? 2017 The Author(s).
SDGs
Other Subjects
adult; aged; atypical mycobacteriosis; atypical Mycobacterium; chronic obstructive lung disease; clinical trial; embryology; female; human; lung; lung tuberculosis; male; metabolism; microbiology; middle aged; multicenter study; pathogenicity; retrospective study; risk factor; statistical model; Taiwan; Adult; Aged; Female; Humans; Logistic Models; Lung; Male; Middle Aged; Mycobacterium avium-intracellulare Infection; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Risk Factors; Taiwan; Tuberculosis, Pulmonary
Publisher
Nature Publishing Group
Type
journal article