https://scholars.lib.ntu.edu.tw/handle/123456789/512463
標題: | Dynamic changes in positive interferon-gamma release assay in a dialysis population: An observational cohort study | 作者: | CHIN-CHUNG SHU VIN-CENT WU FENG-JUNG YANG CHIA-LIN HSU SUNG-CHING PAN JANN-YUAN WANG JANN-TAY WANG CHONG-JEN YU LI-NA LEE |
公開日期: | 2013 | 卷: | 67 | 期: | 6 | 起(迄)頁: | 529-535 | 來源出版物: | Journal of Infection | 摘要: | Background: Interferon-gamma release assay (IGRA) is popular for detecting latent tuberculosis infection (LTBI), but its dynamic change is uncertain in high-risk groups such as dialysis patients. Methods: Patients undergoing dialysis were prospectively enrolled. The QuantiFERON-TB Gold In-Tube (QFT-GIT) was used to detect LTBI. After 6 and 12 months, QFT-GIT was repeated to monitor dynamic changes. Results: Only 204 of 391 enrolled patients completed the study. The initial QFT-GIT positive rate of 22.1% decreased to 19.6% after 6 months and to 14.2% after 12 months. The 6-month reversion rate was 45.9% while the conversion rate was 7.7%. Sub-population with new QFT-GIT positivity had 87.5% reversion rate, higher than the 20.8% of patients with persistent QFT-GIT positivity. The QFT-GIT response was independently associated with persistent QFT-GIT positivity. Using 0.93IU/ml of the initial QFT-GIT response as the threshold can detect 79% persistent positivity in 6-month follow-up. Prior TB had a borderline significance for predicting conversion. Conclusions: In the dialysis population, reversion and conversion occur frequently within six months. The QFT-GIT positive population is heterogeneous and sub-populations have different reversion rates. Higher QFT-GIT positivity threshold can identify patients with persistent QFT-GIT positivity to prioritize follow-up and LTBI therapy. ? 2013 The British Infection Association. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887016600&doi=10.1016%2fj.jinf.2013.07.029&partnerID=40&md5=ac9d109caa98a5a1e6c6acf89204c619 https://scholars.lib.ntu.edu.tw/handle/123456789/512463 |
ISSN: | 0163-4453 | DOI: | 10.1016/j.jinf.2013.07.029 | SDG/關鍵字: | adult; article; clinical trial; cohort analysis; diagnostic equipment; diagnostic value; female; follow up; hemodialysis patient; human; interferon gamma release assay; latent tuberculosis; major clinical study; male; observational study; outcome assessment; prospective study; Conversion; Dialysis; Interferon-gamma release assay; Latent tuberculosis infection; Reversion; Aged; Female; Humans; Interferon-gamma Release Tests; Latent Tuberculosis; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Renal Dialysis |
顯示於: | 醫學系 |
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