Apoptosis-associated biomarkers in tuberculosis: Promising for diagnosis and prognosis prediction
Journal
BMC Infectious Diseases
Journal Volume
13
Journal Issue
1
Pages
45
Date Issued
2013
Author(s)
Wu M.-F.
Hsieh S.-L.
Abstract
Background: Apoptosis-associated biomarkers are rarely studied, especially their role in predicting the development of tuberculosis (TB) from latent TB infection and in prognostication.Methods: Patients with TB and interferon-gamma release assay (IGRA)-positive and IGRA-negative family contacts were evaluated to analyze changes in apoptosis-associated serum biomarkers, which included decoy receptor 3 (DcR3), prostaglandin 2 (PGE2), and lipoxin. The prognostic implications of these serum biomarkers were also analyzed.Results: One hundred TB patients and 92 IGRA-negative and 91 IGRA-positive family contacts were recruited. The DcR3 and PGE2 levels decreased from the IGRA-negative group to the IGRA-positive group, and peaked in the TB group. Lipoxin decreased to trough in the TB group. The three apoptosis serum markers and age were independent factors discriminating active TB from latent TB infection. In active TB, older age, co-morbidity, and higher serum DcR3 and monocyte chemotactic protein (MCP)-1 were independently associated with poorer six-month survival.Conclusion: Apoptosis-associated serum biomarkers change along with the status of Mycobacterium tuberculosis infection. In close contacts with positive IGRA, high DcR3 and PGE2 and low lipoxin may increase the probability of active TB. Older age, co-morbidity, and high DcR3 and MCP-1 levels might be important prognostic factors that warrant further investigation. ? 2013 Shu et al.; licensee BioMed Central Ltd.
SDGs
Other Subjects
biological marker; decoy receptor 3; interleukin 10; interleukin 6; lipoxin; macrophage inflammatory protein 1alpha; macrophage inflammatory protein 1beta; monocyte chemotactic protein 1; prostaglandin E2; tumor necrosis factor alpha; adult; age; apoptosis; article; comorbidity; controlled study; disease activity; family; female; human; interferon gamma release assay; major clinical study; male; prediction; prognosis; prospective study; survival time; tuberculosis; Adult; Aged; Aged, 80 and over; Apoptosis; Biological Markers; Cytokines; Female; Humans; Latent Tuberculosis; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; ROC Curve; Tuberculosis
Type
journal article