Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Predicting results of mycobacterial culture on sputum smear reversion after anti-tuberculous treatment: A case control study
 
  • Details

Predicting results of mycobacterial culture on sputum smear reversion after anti-tuberculous treatment: A case control study

Journal
BMC Infectious Diseases
Journal Volume
10
Pages
48
Date Issued
2010
Author(s)
CHIN-CHUNG SHU  
JANN-TAY WANG  
Lee C.-H.
JANN-YUAN WANG  
LI-NA LEE  
CHONG-JEN YU  
DOI
10.1186/1471-2334-10-48
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952299399&doi=10.1186%2f1471-2334-10-48&partnerID=40&md5=c68040b25927071b14dc6221a064c0d3
https://scholars.lib.ntu.edu.tw/handle/123456789/512505
Abstract
Background: Little is currently known regarding sputum smear reversion (acid-fast smear becomes positive again after negative conversion) during anti-tuberculous treatment. This study aimed to evaluate its occurrence in patients with pulmonary tuberculosis (TB) and identify factors predicting results of mycobacterial culture for smear-reversion of sputum samples.Methods: The retrospective review was performed in a tertiary referral center and a local teaching hospital in Taiwan. From 2000 to 2007, patients with smear-positive culture-confirmed pulmonary TB experiencing smear reversion after 14 days of anti-tuberculous treatment were identified.Results: The 739 patients with smear-positive pulmonary TB had 74 (10%) episodes of sputum smear reversion that grew Mycobacterium tuberculosis in 22 (30%) (Mtb group). The remaining 52 episodes of culture-negative sputum samples were classified as the non-Mtb group. The anti-tuberculous regimen was modified after confirming smear reversion in 15 (20%). Fourteen episodes in the Mtb group and 15 in the non-Mtb group occurred during hospitalization. All were admitted to the negative-pressure rooms at the time of smear reversion. Statistical analysis showed that any TB drug resistance, smear reversion within the first two months of treatment or before culture conversion, and the absence of radiographic improvement before smear reversion were associated with the Mtb group. None of the smear reversion was due to viable M. tuberculosis if none of the four factors were present.Conclusions: Sputum smear reversion develops in 10% of patients with smear-positive pulmonary TB, with 30% due to viable M. tuberculosis bacilli. Isolation and regimen modification may not be necessary for all drug-susceptible patients who already have radiographic improvement and develop smear reversion after two months of treatment or after sputum culture conversion. ? 2010 Shu et al; licensee BioMed Central Ltd.
SDGs

[SDGs]SDG3

Other Subjects
ethambutol; isoniazid; pyrazinamide; rifampicin; tuberculostatic agent; tuberculostatic agent; aged; antibiotic resistance; article; bacterial growth; bacterium culture; controlled study; drug efficacy; female; hospitalization; human; lung tuberculosis; major clinical study; male; Mycobacterium tuberculosis; patient monitoring; retrospective study; sputum culture; sputum smear; case control study; cytology; isolation and purification; microbiology; microscopy; pathology; recurrent disease; sputum; Taiwan; teaching hospital; thorax radiography; tuberculosis; Aged; Aged, 80 and over; Antitubercular Agents; Case-Control Studies; Drug Resistance, Bacterial; Female; Hospitals, Teaching; Humans; Male; Microscopy; Mycobacterium tuberculosis; Radiography, Thoracic; Recurrence; Retrospective Studies; Sputum; Taiwan; Tuberculosis
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science