Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/512508
Title: Adding moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis
Authors: JANN-YUAN WANG 
JANN-TAY WANG 
TZU-HSIU TSAI 
CHIA-LIN HSU 
CHONG-JEN YU 
PO-REN HSUEH 
LI-NA LEE 
PAN-CHYR YANG 
Issue Date: 2010
Journal Volume: 14
Journal Issue: 1
Start page/Pages: 65-71
Source: International Journal of Tuberculosis and Lung Disease
Abstract: 
OBJECTIVE: To investigate whether adding moxifloxacin (MXF) to the standard anti-tuberculosis regimen can shorten the time to sputum culture conversion in pulmonary tuberculosis (PTB). METHODS: Adults with culture-positive PTB were divided into two treatment groups by their choice: standard regimen alone (HERZ group) and standard regimen plus daily 400 mg MXF in the first 2 months (MXF group). Sputum samples were collected thrice weekly in the first 8 weeks. The propensity score was calculated to estimate the conditional probability of entering the MXF group. Factors influencing time to culture conversion were investigated using Cox proportional hazards regression analysis stratified by propensity score. RESULTS: Sixty-two patients were enrolled in the MXF group and 88 in the HERZ group; respectively 51 and 72 completed the study. The regimen was modified before culture conversion in respectively 6 (12%) and 12 (16%; P = 0.47) patients, due to adverse effects. The time to culture conversion was shorter in the MXF group (HR 2.1, 95%CI 1.4-3.2). The culture conversion rate after 6 weeks of treatment was respectively 82% and 61% (P = 0.011, <0.05/4, calculated using the modified Bonferroni method). CONCLUSIONS: Adding MXF to the standard antituberculosis regimen in the first 2 months was associated with a shorter time to culture conversion, a higher 6-week culture conversion rate and reduced transmission of tuberculosis. ?2010 The Union.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-76149124232&partnerID=40&md5=1791554d70162596a4820ecd685043f0
https://scholars.lib.ntu.edu.tw/handle/123456789/512508
ISSN: 1027-3719
SDG/Keyword: ethambutol; isoniazid; moxifloxacin; pyrazinamide; rifampicin; acute kidney failure; add on therapy; adult; article; blurred vision; calculation; controlled study; dizziness; drug fatality; female; gastrointestinal symptom; gout; human; hyperuricemia; liver function; lung tuberculosis; major clinical study; male; priority journal; proportional hazards model; rash; side effect; sputum analysis; sputum culture; thrombocytopenia; treatment duration; upper gastrointestinal bleeding; Adult; Aged; Antitubercular Agents; Aza Compounds; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mycobacterium tuberculosis; Proportional Hazards Models; Prospective Studies; Quinolines; Sputum; Taiwan; Time Factors; Tuberculosis, Pulmonary
[SDGs]SDG3
Appears in Collections:醫學系

Show full item record

SCOPUSTM   
Citations

48
checked on May 17, 2023

WEB OF SCIENCETM
Citations

43
checked on May 24, 2023

Page view(s)

47
checked on Jun 3, 2023

Google ScholarTM

Check

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback