https://scholars.lib.ntu.edu.tw/handle/123456789/512585
標題: | A rare epidermal growth factor receptor H773L/V774M compound mutation in advanced non-small-cell lung cancer with poor response to epidermal growth factor receptor tyrosine kinase inhibitor | 作者: | LUN-CHE CHEN JIN-YUAN SHIH CHONG-JEN YU Yang C.-Y. |
公開日期: | 2019 | 出版社: | Wiley-Blackwell Publishing Ltd | 卷: | 7 | 期: | 5 | 起(迄)頁: | e00425 | 來源出版物: | Respirology Case Reports | 摘要: | Uncommon mutations account for 10–15% of epidermal growth factor receptor (EGFR) mutations in patients with non-small-cell lung cancer. Afatinib is currently the most efficient EGFR-tyrosine kinase inhibitor (TKI) against uncommon EGFR mutations. Here we report a 56-year-old woman presenting with persistent cough for one month. She was diagnosed with stage IV lung adenocarcinoma by bronchoscopic biopsy to the left lower lung tumour and serial image modalities. A rare H773L/V774M compound mutation in exon 20 was detected by gene sequencing. The patient received first-line afatinib but primary resistance was noted with rapid left lower lung tumour progression. Second-line chemotherapy combined with bevacizumab, pemetrexed, and cisplatin demonstrated more durable response. Our case suggests that H773L/V774M may be one of the EGFR-TKI-resistant uncommon EGFR mutations. ? 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065498754&doi=10.1002%2frcr2.425&partnerID=40&md5=8b23718132292101f19e41007b38f1dc https://scholars.lib.ntu.edu.tw/handle/123456789/512585 |
ISSN: | 2051-3380 | DOI: | 10.1002/rcr2.425 | SDG/關鍵字: | afatinib; bevacizumab; cisplatin; docetaxel; epidermal growth factor receptor; pemetrexed; protein tyrosine kinase inhibitor; ramucirumab; adaptive immunity; adrenal gland; adult; Article; biopsy; bronchoscopy; case report; clinical article; coughing; disease exacerbation; DNA extraction; evaluation and follow up; exon; female; gene mutation; gene sequence; human; lung adenocarcinoma; lung metastasis; mediastinum lymph node; middle aged; multiple cycle treatment; non small cell lung cancer; radiation dose; supraclavicular lymph node; tumor growth; whole brain radiotherapy |
顯示於: | 醫學系 |
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