Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-sensitive Exon 19 Insertion and Exon 20 Insertion in Patients With Advanced Non–Small-cell Lung Cancer
 
  • Details

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-sensitive Exon 19 Insertion and Exon 20 Insertion in Patients With Advanced Non–Small-cell Lung Cancer

Journal
Clinical Lung Cancer
Journal Volume
18
Journal Issue
3
Pages
324-3320
Date Issued
2017
Author(s)
YEN-TING LIN  
Liu Y.-N.
SHANG-GIN WU  
CHIH-HSIN YANG  
JIN-YUAN SHIH  
DOI
10.1016/j.cllc.2016.12.014
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009788835&doi=10.1016%2fj.cllc.2016.12.014&partnerID=40&md5=ebe2b17f3dda02d704b5b090fa5a6ccd
https://scholars.lib.ntu.edu.tw/handle/123456789/512616
Abstract
We analyzed the responsiveness of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) to 2 rare EGFR mutations, exon 19 insertion and exon 20 insertion (A763_Y764 insFQEA). The response rate for exon 19 insertion was 56%, and the median time to progression was 10.4 months. The response rate for exon 20 insertion (A763_Y764 insFQEA) was 73%, and the median time to progression was 5.0 months. Both showed sensitivity to EGFR TKIs. Background The clinical responsiveness to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non–small-cell lung cancer (NSCLC) patients with exon 19 insertion and the specific exon 20 insertion (A763_Y764 insFQEA) are still not well known. Materials and Methods We analyzed cancer specimens taken from NSCLC patients for EGFR mutations using RNA reverse transcription polymerase chain reaction or direct DNA sequencing. The clinical course and responsiveness to an EGFR TKI in patients with EGFR exon 19 insertion or exon 20 insertion (A763_Y764 insFQEA) were recorded. The published data regarding these mutations were also reviewed. Results From September 1995 to May 2015, we found 4 patients with an EGFR exon 19 insertion and 6 patients with an EGFR exon 20 insertion (A763_Y764 insFQEA) at the National Taiwan University Hospital. Among patients with an exon 19 insertion, 3 received an EGFR TKI. Of the 3 patients, 1 had a partial response, 1 had stable disease, and 1 had progressive disease. Of the 6 patients with the exon 20 insertion (A763_Y764 insFQEA), 3 received an EGFR TKI. Of those 3 patients, 2 had a partial response and 1 had progressive disease. A review of the published data, together with the data from our patients, patients with an exon 19 insertion and treated with an EGFR TKI (n = 18) had a response rate of 56% and a median time to progression of 10.4 months. Patients with the exon 20 insertion (A763_Y764 insFQEA) and treated with an EGFR TKI (n = 11) had a response rate of 73% and a median time to progression of 5.0 months. Conclusions Advanced NSCLC bearing the EGFR exon 19 insertion or exon 20 insertion (A763_Y764 insFQEA) is sensitive to EGFR TKIs. ? 2016 Elsevier Inc.
SDGs

[SDGs]SDG3

Other Subjects
afatinib; carboplatin; cisplatin; epidermal growth factor receptor; epidermal growth factor receptor kinase inhibitor; erlotinib; gefitinib; gemcitabine; pemetrexed; tesevatinib; vinorelbine tartrate; protein kinase inhibitor; adjuvant therapy; adult; advanced cancer; aged; Article; cancer adjuvant therapy; cancer combination chemotherapy; cancer patient; clinical article; DNA sequence; exon; female; gene insertion; human; human tissue; male; middle aged; non small cell lung cancer; nucleotide sequence; overall survival; post treatment survival; reverse transcription polymerase chain reaction; treatment response; cancer staging; drug resistance; exon; gene expression regulation; genetics; lung tumor; non small cell lung cancer; pathology; proto oncogene; Taiwan; Aged; Carcinoma, Non-Small-Cell Lung; Drug Resistance; Erlotinib Hydrochloride; Exons; Female; Genes, erbB-1; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenesis, Insertional; Neoplasm Staging; Protein Kinase Inhibitors; Taiwan
Publisher
Elsevier Inc.
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science