Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
Journal
Frontiers in immunology
Journal Volume
10
Journal Issue
AUG
Date Issued
2019
Author(s)
Bluyssen, Hans A R
Abstract
Signal Transducer and Activator of Transcription (STAT) and Interferon Regulatory Factor (IRF) are important transcriptional regulators that modulate crucial aspect of innate and adaptive immunity. Among their activating signals are cytokines and growth factors, including interferons (IFNs), interleukins (ILs), and growth factors like EGF and PDGF. Also many oncogenic signals and pathogenic responses, dependent on pattern-recognition receptors (PRRs), are among STAT and IRF activators.
Subjects
IRF; STAT; innate immunity; therapeutic target; transcription regulation
SDGs
Publisher
FRONTIERS MEDIA SA
Type
editorial