Combination Therapy of Pulsed-Wave Ultrasound Hyperthermia and Immunostimulant OK-432 Enhances Systemic Antitumor Immunity for Cancer Treatment
Journal
International journal of radiation oncology, biology, physics
Date Issued
2020-04-25
Author(s)
Abstract
In this study, we hypothesized that systemic antitumor immunity might be enhanced by combining pulsed-wave ultrasound hyperthermia (pUSHT) with OK-432 and that the induced antitumor immunity could confer protection against tumorigenesis. These hypotheses were tested in bilateral and rechallenged tumor models.
SDGs
Other Subjects
Cell death; Diseases; Growth rate; Hyperthermia therapy; Mammals; T-cells; Ultrasonics; Anti-tumor immune; Antitumor immunity; Combination therapy; Combination treatments; Methods and materials; Pulsed-wave ultrasound; Surgical resection; Therapeutic strategy; Tumors; CD4 antigen; CD8 antigen; gamma interferon; picibanil; immunological adjuvant; picibanil; animal experiment; animal model; antineoplastic activity; Article; bilateral cancer; cancer combination chemotherapy; cancer survival; carcinogenesis; CD4+ T lymphocyte; CD8+ T lymphocyte; cell infiltration; chemoradiotherapy; controlled study; female; hyperthermia; immune response; immunocompetent cell; mouse; natural killer cell; nonhuman; priority journal; protection; pulsed ultrasound; survival rate; thermotherapy; treatment duration; tumor growth; tumor immunity; tumor volume; ultrasound therapy; animal; cell proliferation; drug effect; multimodality cancer therapy; thermotherapy; tumor cell line; ultrasound; Adjuvants, Immunologic; Animals; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Hyperthermia, Induced; Mice; Picibanil; Ultrasonic Waves
Type
journal article