https://scholars.lib.ntu.edu.tw/handle/123456789/514446
標題: | Hepatitis C virus infection as a risk factor for Parkinson disease | 作者: | Tsai H.-H. HORNG-HUEI LIOU Muo C.-H. Lee, Cha-Ze RUOH-FANG YEN Kao C.-H. |
公開日期: | 2016 | 卷: | 86 | 期: | 9 | 起(迄)頁: | 840-846 | 來源出版物: | Neurology | 摘要: | Objective: To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD). Methods: This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The crude HRs for developing PD was 0.66 (95% CI 0.55-0.80) for HBV infection, 2.50 (95% CI 2.07-3.02) for HCV infection, and 1.28 (95% CI 0.88-1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR 1.29, 95% CI 1.06-1.56). Conclusions: We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD. ? 2016 American Academy of Neurology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/514446 | ISSN: | 0028-3878 | DOI: | 10.1212/WNL.0000000000002307 | SDG/關鍵字: | adult; aged; Article; cerebrovascular accident; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease association; epilepsy; female; follow up; head injury; hepatitis B; hepatitis C; human; hyperlipidemia; hypertension; ICD-9-CM; incidence; ischemic heart disease; liver cirrhosis; major clinical study; male; Parkinson disease; priority journal; risk assessment; age distribution; epidemiology; hepatitis C; middle aged; Parkinson disease; reproducibility; sensitivity and specificity; sex ratio; Taiwan; Adult; Age Distribution; Aged; Causality; Cohort Studies; Comorbidity; Female; Hepatitis C; Humans; Incidence; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Sex Distribution; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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