Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
Journal
NeuroImage
Journal Volume
31
Journal Issue
1
Pages
301-307
Date Issued
2006
Author(s)
Abstract
Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted tool for the treatment of Parkinson's disease (PD). Although the precise mechanism of action of this intervention is unknown, its effectiveness has been attributed to the modulation of pathological network activity. We examined this notion using positron emission tomography (PET) to quantify stimulation-induced changes in the expression of a PD-related covariance pattern (PDRP) of regional metabolism. These metabolic changes were also compared with those observed in a similar cohort of patients undergoing STN lesioning. We found that PDRP activity declined significantly (P?
SDGs
Other Subjects
adult; aged; article; brain depth stimulation; brain region; clinical article; controlled study; female; globus pallidus; human; male; mesencephalon; Parkinson disease; positron emission tomography; priority journal; statistical parameters; subthalamic nucleus; Aged; Analysis of Variance; Blood Glucose; Brain Mapping; Cerebellum; Cerebral Cortex; Corpus Striatum; Deep Brain Stimulation; Energy Metabolism; Female; Fluorodeoxyglucose F18; Globus Pallidus; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Nerve Net; Neural Pathways; Parkinson Disease; Positron-Emission Tomography; Subthalamic Nucleus; Thalamus
Type
journal article