https://scholars.lib.ntu.edu.tw/handle/123456789/514760
標題: | Negative association between acrylamide exposure and body composition in adults: NHANES, 2003-2004 | 作者: | Chu P.-L. LIAN-YU LIN PAU-CHUNG CHEN TA-CHEN SU Lin C.-Y. |
公開日期: | 2017 | 出版社: | Nature Publishing Group | 卷: | 7 | 期: | 3 | 起(迄)頁: | e246 | 來源出版物: | Nutrition and Diabetes | 摘要: | Background/Objectives: Acrylamide is present in mainstream cigarette smoke and in some food prepared at high temperature. Animal studies have shown that acrylamide exposure reduces body weight. Prenatal exposure to acrylamide also has been linked to reduced birth weight in human. Whether acrylamide exposure is associated with altered body compositions in adults is not clear.Subjects/Methods: We selected 3623 subjects (aged ?20 years) from a National Health and Nutrition Examination Survey (NHANES) in 2003-2004 to determine the relationship among hemoglobin adducts of acrylamide (HbAA), hemoglobin adducts of glycidamide (HbGA) and body composition (body measures, bioelectrical impedance analysis (BIA), dual energy X-ray absorptiometry (DXA)). Data were adjusted for potential confounding variables.Results:The geometric means and 95% CI concentrations of HbAA and HbGA were 60.48 (59.32-61.65) pmol/g Hb and 55.64 (54.40-56.92) pmol/g Hb, respectively. After weighting for sampling strategy, we identified that one-unit increase in natural log-HbAA, but not HbGA, was associated with reduction in body measures (body weight, body mass index (BMI), subscapular/triceps skinfold), parameters of BIA (fat-free mass, fat mass, percent body fat, total body water) and parameters of DXA (android fat mass, android percent fat, gynoid fat/lean mass, gynoid percent mass, android to gynoid ratio). Subgroup analysis showed that these associations were more evident in subjects at younger age, male gender, whites, lower education level, active smokers and those with lower BMI.Conclusions:Higher concentrations of HbAA are associated with a decrease in body composition in the US general population. Further studies are warranted to clarify this association. ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015263282&doi=10.1038%2fnutd.2016.48&partnerID=40&md5=664b8edd0e71789fda17bf9b15bbbc13 https://scholars.lib.ntu.edu.tw/handle/123456789/514760 |
ISSN: | 2044-4052 | DOI: | 10.1038/nutd.2016.48 | SDG/關鍵字: | acrylamide; caffeine; chloride; hemoglobin; hemoglobin A; hemoglobin gamma chain; saturated fatty acid; acrylamide; hemoglobin; adult; age; Black person; body composition; body fat; body mass; body water; body weight; Caucasian; chloride blood level; correlational study; dual energy X ray absorptiometry; educational status; environmental exposure; fat intake; fat mass; female; gender; hemoglobin blood level; high school; Hispanic; household income; human; impedance; lean body weight; major clinical study; male; Mexican American; middle aged; priority journal; Review; skinfold thickness; smoking; young adult; body composition; drug effects; nutrition; photon absorptiometry; Absorptiometry, Photon; Acrylamide; Adult; Body Composition; Electric Impedance; Female; Hemoglobins; Humans; Male; Middle Aged; Nutrition Surveys; Young Adult |
顯示於: | 醫學系 |
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