https://scholars.lib.ntu.edu.tw/handle/123456789/514774
標題: | Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration | 作者: | KUO-LIONG CHIEN Thompson S.G. Agewall S. Bergström G. Bickel H. Catapano A.L. Chien K.-L. De Groot E. Empana J.-P. Etgen T. Franco O.H. Iglseder B. Johnsen S.H. Kavousi M. Lind L. Liu J. Mathiesen E.B. Norata G.D. Olsen M.H. Papagianni A. Poppert H. Price J.F. Sacco R.L. Yanez D.N. Zhao D. Schminke U. Bülbül A. Polak J.F. Sitzer M. Hofman A. Grigore L. Dörr M. TA-CHEN SU Ducimetière P. Xie W. Ronkainen K. Kiechl S. Rundek T. Robertson C. Fagerberg B. Bokemark L. Steinmetz H. Ikram M.A. Völzke H. HUNG-JU LIN Plichart M. Tuomainen T.-P. Desvarieux M. McLachlan S. Schmidt C. Kauhanen J. Willeit J. Lorenz M.W. Sander D. |
公開日期: | 2016 | 出版社: | SAGE Publications Inc. | 卷: | 23 | 期: | 2 | 起(迄)頁: | 194-205 | 來源出版物: | European Journal of Preventive Cardiology | 摘要: | Background Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Methods Information on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. Results Mean baseline CCA-IMT amounted to 0.74 mm (SD = 0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011 mm/year (SD = 0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082 mm for high-sensitivity C-reactive protein (p < 0.001); 0.0072 mm for fibrinogen (p < 0.001); and 0.0025 mm for leucocyte count (p = 0.033). 'Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p < 0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest 'inflammatory load' had a greater CCA-IMT progression (p = 0.015). Conclusion Inflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for 'inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis. ? 2014 European Society of Cardiology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953253796&doi=10.1177%2f2047487314560664&partnerID=40&md5=305018d8256acd86bb4a5dd6cac9bb39 https://scholars.lib.ntu.edu.tw/handle/123456789/514774 |
ISSN: | 2047-4873 | DOI: | 10.1177/2047487314560664 | SDG/關鍵字: | biological marker; C reactive protein; fibrinogen; biological marker; C reactive protein; fibrinogen; arterial wall thickness; atherosclerosis; cohort analysis; cross-sectional study; disease course; human; inflammation; leukocyte count; priority journal; Review; atherosclerosis; blood; disease course; inflammation; leukocyte count; meta analysis; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Intima-Media Thickness; Disease Progression; Fibrinogen; Humans; Inflammation; Leukocyte Count |
顯示於: | 醫學系 |
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