https://scholars.lib.ntu.edu.tw/handle/123456789/514780
標題: | Carotid intima-media thickness and long-term exposure to traffic-related air pollution in middle-aged residents of Taiwan: A cross-sectional study | 作者: | TA-CHEN SU HWANG, JUEY-JEN Shen Y.-C. CHANG-CHUAN CHAN |
公開日期: | 2015 | 出版社: | Public Health Services, US Dept of Health and Human Services | 卷: | 123 | 期: | 8 | 起(迄)頁: | 773-778 | 來源出版物: | Environmental Health Perspectives | 摘要: | Background: Associations between long-term exposure to air pollution and carotid intima-media thickness (CIMT) have inconsistent findings. Objectives: In this study we aimed to evaluate association between 1-year average exposure to traffic-related air pollution and CIMT in middle-aged adults in Asia. Methods: CIMT was measured in Taipei, Taiwan, between 2009 and 2011 in 689 volunteers 35–65 years of age who were recruited as the control subjects of an acute coronary heart disease cohort study. We applied land-use regression models developed by the European Study of Cohorts for Air Pollution Effects (ESCAPE) to estimate each subject’s 1-year average exposure to trafficrelated air pollutants with particulate matter diameters ≤ 10 μm (PM10) and ≤ 2.5 μm (PM2.5) and the absorbance levels of PM2.5 (PM2.5abs), nitrogen dioxide (NO2), and nitrogen oxides (NOx) in the urban environment. Results: One-year average air pollution exposures were 44.21 ± 4.19 μg/m3 for PM10, 27.34 ± 5.12 μg/m3 for PM2.5, and (1.97 ± 0.36) × 10–5/m for PM2.5abs. Multivariate regression analyses showed average percentage increases in maximum left CIMT of 4.23% (95% CI: 0.32, 8.13) per 1.0 × 10–5/m increase in PM2.5abs; 3.72% (95% CI: 0.32, 7.11) per 10-μg/m3 increase in PM10; 2.81% (95% CI: 0.32, 5.31) per 20-μg/m3 increase in NO2; and 0.74% (95% CI: 0.08, 1.41) per 10-μg/m3 increase in NOx. The associations were not evident for right CIMT, and PM2.5 mass concentration was not associated with the outcomes. Conclusions: Long-term exposures to traffic-related air pollution of PM2.5abs, PM10, NO2, and NOx were positively associated with subclinical atherosclerosis in middle-aged adults. © 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938322072&doi=10.1289%2fehp.1408553&partnerID=40&md5=c858e889c14dce2c7889b63fd278bd34 https://scholars.lib.ntu.edu.tw/handle/123456789/514780 |
ISSN: | 0091-6765 | DOI: | 10.1289/ehp.1408553 | SDG/關鍵字: | glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; nitrogen dioxide; nitrogen oxide; triacylglycerol; air pollutant; exhaust gas; nitrogen oxide; particulate matter; adult; aged; air pollution; arterial wall thickness; Article; cardiovascular risk; carotid atherosclerosis; case control study; common carotid artery; controlled study; cross-sectional study; diastolic blood pressure; disease association; environmental exposure; exhaust gas; female; geographic information system; human; hypercholesterolemia; ischemic heart disease; long term exposure; major clinical study; male; middle aged; oral glucose tolerance test; particulate matter; priority journal; systolic blood pressure; Taiwan; traffic; adverse effects; air pollutant; chemically induced; coronary artery disease; exhaust gas; particle size; season; statistics and numerical data; theoretical model; toxicity; Adult; Aged; Air Pollutants; Air Pollution; Carotid Intima-Media Thickness; Coronary Artery Disease; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Male; Middle Aged; Models, Theoretical; Nitrogen Oxides; Particle Size; Particulate Matter; Seasons; Taiwan; Vehicle Emissions |
顯示於: | 醫學系 |
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