https://scholars.lib.ntu.edu.tw/handle/123456789/514784
標題: | Additive effects of postchallenge hyperglycemia and low-density lipoprotein particles on the risk of arterial stiffness in healthy adults | 作者: | Ding C. SANDY HUEY-JEN HSU Wu Y.-J. TA-CHEN SU |
公開日期: | 2014 | 出版社: | BioMed Central Ltd. | 卷: | 13 | 期: | 1 | 起(迄)頁: | 179 | 來源出版物: | Lipids in Health and Disease | 摘要: | Background: To determine the effects of post-challenge hyperglycemia potentiate low-density lipoprotein cholesterol (LDL) particles on the risk of arterial stiffness in non-diabetic adults. Methods: During 2009-2011, 592 adults without clinical diabetes (fasting glucose <7.0 mmol/L) or known coronary heart disease or stroke were recruited. All subjects underwent standard 75-g oral glucose tolerance test (OGTT) after overnight fasting. The glucose area under curve (GluAUC) after OGTT was defined as the postchallenge glucose load. Levels of LDL-C and small dense LDL-C (sdLDL-C) were measured. Arterial stiffness in terms of brachial-ankle pulse wave velocity (baPWV) was also measured. Results: The baPWV in tertile distributions were significantly associated with all conventional cardiovascular risk factors, LDL-C, and sdLDL-C. Multivariate logistic regression analyses revealed that LDL-C (or sdLDL-C) combined with one of the seven glycemic indices (glucose levels at 0, 30, 60, 90, and 120 min; GluAUC; HbA1C) was associated with arterial stiffness after covariates being adjusted. Further interaction analyses showed only concurrent higher levels of both glycemic indices and atherogenic LDL-C or sdLDL-C have significant risk for arterial stiffness. Conclusions: Additive effects of both postchallenge hyperglycemia and LDL subclass particles potentiate the risk of arterial stiffness. The adverse joint effects of hyperlipidemia and postchallenge hyperglycemia on subclinical cardiovascular function provide important information in primary prevention of cardiovascular disease in subjects without clinical diabetes. ? 2014 Ding et al.; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976871005&doi=10.1186%2f1476-511X-13-179&partnerID=40&md5=80d944c710a96613a0ccb12fdd88276a https://scholars.lib.ntu.edu.tw/handle/123456789/514784 |
ISSN: | 1476-511X | DOI: | 10.1186/1476-511X-13-179 | SDG/關鍵字: | glucose; hemoglobin A1c; low density lipoprotein cholesterol; low density lipoprotein; adult; ankle brachial index; area under the curve; arterial stiffness; Article; cardiovascular risk; diet restriction; female; glucose blood level; glycemic index; human; human experiment; hyperglycemia; male; multivariate logistic regression analysis; normal human; oral glucose tolerance test; pulse wave; risk assessment; volunteer; blood; hyperglycemia; middle aged; postprandial state; risk factor; young adult; Adult; Female; Humans; Hyperglycemia; Lipoproteins, LDL; Male; Middle Aged; Postprandial Period; Risk Factors; Vascular Stiffness; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。