https://scholars.lib.ntu.edu.tw/handle/123456789/514879
標題: | Nitric oxide production is paradoxically decreased after weight reduction surgery in morbid obesity patients | 作者: | LIAN-YU LIN Lee W.-J. Shen H.-N. WEI-SHIUNG YANG Pai N.-H. TA-CHEN SU Liau C.-S. |
公開日期: | 2007 | 卷: | 190 | 期: | 2 | 起(迄)頁: | 436-442 | 來源出版物: | Atherosclerosis | 摘要: | Obesity is associated with vascular endothelial cell dysfunction (ECD). Studies on nitric oxide (NO) production of vascular system in these subjects may help delineate the pathogenesis of obesity-associated ECD. In this study, we recruited 69 severely obese patients who were treated with gastric partition surgery for weight reduction and 69 matched healthy controls for comparison. The following parameters were obtained in the healthy control subjects and in the obese subjects both before and after gastric partition surgery: body mass index, blood pressure, serum lipids, high sensitivity C-reactive protein (hs-CRP), adiponectin, total nitrite and nitrate (NOx), and 8-iso-prostaglandin F2α (8-iso-PGF2α), and insulin resistance index (as measured by homeostasis model assessment (HOMA-IR). At baseline, serum lipids, glucose, insulin, hs-CRP and 8-iso-PGF2α and HOMA-IR were all higher while adiponectin lower in the obese group than in the control group. The serum NOx levels were not different between the two groups. In the obese subjects, the adiponectin levels were significantly elevated but NOx markedly decreased after surgery. All other measurements, except for systolic blood pressure, were decreased after surgery. For healthy controls, the serum NOx levels were negatively associated with HOMA-IR and positively associated with serum adiponectin levels as analyzed by multiple linear regression analysis. In obese patients, the baseline serum NOx was positively associated with the serum TG levels. The changes of serum NOx levels after weight reduction surgery were positively associated with the changes of body mass index and serum TG levels. These observations suggested that, in the extremely obese patients, there might be excessive production and/or inactivation of NO and, after weight reduction surgery, the NO production was down-regulated. In conclusion, in the severely obese patients, the apparently normal NO production might be due to over-expression of iNOS. After gastric partition surgery, the NO production was significantly decreased which might be reflecting the usual status of NO production in obese subjects. The positive correlation between NOx and serum TG level might suggest that the metabolism of TG plays a role in the regulation of NO production. ? 2006 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846070613&doi=10.1016%2fj.atherosclerosis.2006.02.033&partnerID=40&md5=4365a8bd4f03cef29db3eac94c331f16 https://scholars.lib.ntu.edu.tw/handle/123456789/514879 |
ISSN: | 0021-9150 | DOI: | 10.1016/j.atherosclerosis.2006.02.033 | SDG/關鍵字: | 8 isoprostaglandin F2 alpha; adiponectin; C reactive protein; glucose; inducible nitric oxide synthase; insulin; lipid; nitrate; nitric oxide; nitrite; triacylglycerol; adult; analytical parameters; article; blood chemistry; body mass; clinical assessment; comparative study; controlled study; down regulation; female; gastric partition surgery; glucose blood level; glucose homeostasis; human; insulin blood level; insulin resistance; lipid blood level; major clinical study; male; morbid obesity; multiple linear regression analysis; postoperative period; preoperative evaluation; priority journal; protein blood level; protein expression; sensitivity analysis; statistical significance; stomach partitioning; stomach surgery; systolic blood pressure; triacylglycerol blood level; weight reduction; Adult; Bariatric Surgery; Body Mass Index; Endothelium, Vascular; Female; Homeostasis; Humans; Male; Middle Aged; Models, Biological; Nitric Oxide; Obesity, Morbid |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。