https://scholars.lib.ntu.edu.tw/handle/123456789/514886
標題: | Major gene effects on apolipoprotein B concentrations in families of adolescents - Results from a community-based study in Taiwan | 作者: | KUO-LIONG CHIEN WEI J. CHEN Hsu, Hsiu-Ching TA-CHEN SU MING-FONG CHEN Lee, Yuan-Teh |
關鍵字: | Apolipoprotein B; Community study; Heritability; Major genes | 公開日期: | 三月-2006 | 卷: | 365 | 期: | 1-2 | 起(迄)頁: | 194 | 來源出版物: | Clinica Chimica Acta | 摘要: | Background: Apolipoprotein (Apo) B is considered as a risk factor for atherosclerosis. Previous reports of segregation analyses on the mode of inheritance of Apo B were inconsistent because of heterogeneity in study population or elderly adult diseased probands. We performed complex segregation analysis of Apo B levels in the families of adolescents, systematically ascertained from junior high school students in a rural community in Taiwan. Results: There is a sex-specific influence in the variation of apo B levels. The mother-daughter (0.216), sister-sister (0.181), sister-brother (0.179) correlations were higher than father-son (0.206), brother-brother (0.002) or cross-sex correlations for the variation in Apo B levels. By the variance component model, the heritability estimate was 26.3 ± 6.7% (P < .0001) in Apo B levels. Commingling analysis indicated that a 2-component distribution was needed to account for Apo B variation. Segregation analysis using regressive models revealed that the best-fit model of Apo B was the model of major gene effect plus familial correlation. The gene frequency controlling high Apo B was 0.17, and 3 means of genotypes were 56.3, 54,2, and 117.2 mg/dl. Conclusion: Variations of Apo B levels in the normal range among adolescent families are controlled by major gene, and further identification of this gene locus will be mandatory. ? 2005 Elsevier B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-32044452886&doi=10.1016%2fj.cca.2005.08.025&partnerID=40&md5=26c54b8f39d19e412b639b078e4821e4 https://scholars.lib.ntu.edu.tw/handle/123456789/514886 http://ntur.lib.ntu.edu.tw//handle/246246/197107 http://ntur.lib.ntu.edu.tw//handle/246246/158803 |
ISSN: | 0009-8981 | DOI: | 10.1016/j.cca.2005.08.025 | SDG/關鍵字: | apolipoprotein B; adolescent; adult; article; controlled study; correlation analysis; gene frequency; gene identification; gene locus; genetic analysis; genotype; heredity; heritability; human; inheritance; major clinical study; priority journal; segregation analysis; sex difference; Taiwan; Adolescent; Apolipoproteins B; Cohort Studies; Female; Humans; Male; Taiwan |
顯示於: | 醫學系 |
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