https://scholars.lib.ntu.edu.tw/handle/123456789/514925
標題: | Hyperinsulinemia and related atherosclerotic risk factors in the population at cardiovascular risk: A community-based study | 作者: | KUO-LIONG CHIEN Lee Y.-T. Sung F.-C. Hsu H.-C. TA-CHEN SU Lin R.S. |
公開日期: | 1999 | 出版社: | American Association for Clinical Chemistry Inc. | 卷: | 45 | 期: | 6 I | 起(迄)頁: | 838-846 | 來源出版物: | Clinical Chemistry | 摘要: | Background: A population-based study was conducted in Taiwan to investigate the prevalence of insulin resistance and high serum insulin concentrations and their relationships with potential atherosclerotic risk factors. Methods: We studied 2165 subjects, ages >35, from a community cohort. Results: The distributions of fasting insulin were skewed to the right, with higher concentrations in women than in men. As age increased, insulin increased in women, but decreased in men. As fasting insulin concentrations increased, postloading insulin, glucose, blood pressure, body mass index, waist-to-hip ratio, total cholesterol, triglycerides, LDL- cholesterol, apoprotein B, plasminogen activator inhibitor 1, tissue plasminogen activator, and fibrinogen increased, but lipoprotein(a), HDL- cholesterol, and apoprotein A1 decreased. Multiple logistic regression showed that obesity, high LDL-cholesterol, and low HDL-cholesterol were significant predictors of hyperinsulinemic status. Conclusion. The study subjects with insulin resistance syndrome and related risk factors may be at risk for atherosclerosis, thrombosis, and other coronary heart diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033037821&doi=10.1093%2fclinchem%2f45.6.838&partnerID=40&md5=c9cbeda665d349ad3a7ad48f2a865601 https://scholars.lib.ntu.edu.tw/handle/123456789/514925 |
ISSN: | 0009-9147 | DOI: | 10.1093/clinchem/45.6.838 | SDG/關鍵字: | apolipoprotein B; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; adult; article; atherosclerosis; body mass; cardiovascular disease; coronary artery disease; coronary risk; female; human; hyperinsulinemia; insulin blood level; ischemic heart disease; lipid blood level; major clinical study; male; population risk |
顯示於: | 醫學系 |
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