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  4. Arterial Stiffness Is Associated with Clinical Outcome and Cardiorenal Injury in Lateralized Primary Aldosteronism
 
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Arterial Stiffness Is Associated with Clinical Outcome and Cardiorenal Injury in Lateralized Primary Aldosteronism

Journal
The Journal of clinical endocrinology and metabolism
Journal Volume
105
Journal Issue
11
Date Issued
2020
Author(s)
CHIEH-KAI CHAN  
WEI-SHIUNG YANG  
YEN-HUNG LIN  
KUO-HOW HUANG  
CHING-CHU LU  
Hu Y.-H.
VIN-CENT WU  
SHIH-CHIEH CHUEH  
TZONG-SHINN CHU  
YUNG-MING CHEN  
DOI
10.1210/clinem/dgaa566
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091191666&doi=10.1210%2fclinem%2fdgaa566&partnerID=40&md5=8657e480070abb29c521912ee75da87a
https://scholars.lib.ntu.edu.tw/handle/123456789/514959
Abstract
Context: The association between arterial stiffness and clinical outcome in lateralized primary aldosteronism (PA) patients after adrenalectomy has not been clearly identified. Objective: We hypothesized that arterial stiffness estimated by brachial-ankle pulse wave velocity (baPWV) before adrenalectomy was associated with the clinical outcomes and cardiorenal injury in lateralized PA patients after adrenalectomy. Design and Patients: We designed a retrospective observational cohort study. We collected lateralized PA patients who had undergone adrenalectomy between 2013 and 2016 from the Taiwan Primary Aldosteronism Investigation database.The primary outcome was achieving complete clinical success at 1 year after adrenalectomy.The secondary outcome was estimated glomerular filtration rate declining over 20% and improved left ventricular mass index. Results: We enrolled 221 patients with lateralized PA (50.7% men; mean age, 51.9 years), of whom 101 patients (45.7%) achieved complete clinical success at the 1-year follow-up assessment after adrenalectomy. Lower baPWV before adrenalectomy (odds ratio = 0.998; 95% confidence interval, 0.996-0.999; P = 0.003) correlated with higher likelihood of complete clinical success by multivariate logistic regression analysis. Multifactorial adjusted generalized additive model demonstrated that preoperative baPWV<1600 cm/sec was significantly associated with complete cure of hypertension. In addition, higher preoperative baPWV was associated with renal function decline and less left ventricular mass regression after adrenalectomy in lateralized PA patients during the follow-up period. Conclusions: Our study demonstrated that the preoperative severe arterial stiffness was associated with absent complete clinical success in lateralized PA patients after adrenalectomy, and this effect may contribute to cardiorenal injury, which at least partially explains kidney function deterioration and lessened regression of heart mass. ? Endocrine Society 2020. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
adrenalectomy; adult; arterial stiffness; Article; brachial-ankle pulse wave velocity; cardiorenal syndrome; clinical outcome; disease severity; female; human; hypertension; major clinical study; male; preoperative period; primary hyperaldosteronism; priority journal; adrenalectomy; aged; ankle brachial index; arterial stiffness; brachial artery; diagnostic imaging; echocardiography; glomerulus filtration rate; hyperaldosteronism; middle aged; pathophysiology; physiology; pulse wave; retrospective study; treatment outcome; Adrenalectomy; Adult; Aged; Ankle Brachial Index; Brachial Artery; Echocardiography; Female; Glomerular Filtration Rate; Humans; Hyperaldosteronism; Male; Middle Aged; Pulse Wave Analysis; Retrospective Studies; Treatment Outcome; Vascular Stiffness
Publisher
NLM (Medline)
Type
journal article

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