Proton Pump Inhibitors Augment the Risk of Major Adverse Cardiovascular Events and End-Stage Renal Disease in Patients With Acute Kidney Injury After Temporary Dialysis
Journal
Clinical Pharmacology and Therapeutics
Journal Volume
107
Journal Issue
6
Pages
1434-1445
Date Issued
2020
Author(s)
Shiao C.-C.
Tsao C.-H.
Chen L.-W.
Chen L.
the National Taiwan University Hospital Study Group on Acute Renal Failure (NSARF)
the National Taiwan University Hospital Study Group on Acute Renal Failure (NSARF)
Abstract
Proton pump inhibitors (PPIs) have been reported to increase the risk of acute and chronic renal disease. However, the data are unclear in patients with acute kidney injury (AKI) requiring dialysis (AKI-D) who are often candidates for PPIs. To investigate this important issue, we identified 26,052 AKI-D patients from Taiwan’s National Health Insurance Research Database weaning from dialysis. During a mean follow-up period of 3.52?years, the PPI users had a higher incidence of end-stage renal disease (ESRD) than the PPI nonusers (P?
SDGs
Other Subjects
proton pump inhibitor; proton pump inhibitor; acute kidney failure; aged; all cause mortality; Article; comorbidity; controlled study; dialysis; end stage renal disease; female; follow up; human; incidence; major adverse cardiac event; major clinical study; male; priority journal; propensity score; risk factor; acute kidney failure; cardiovascular disease; chronic kidney failure; factual database; hemodialysis; middle aged; Taiwan; very elderly; Acute Kidney Injury; Aged; Aged, 80 and over; Cardiovascular Diseases; Databases, Factual; Female; Follow-Up Studies; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Proton Pump Inhibitors; Renal Dialysis; Risk Factors; Taiwan
Publisher
Nature Publishing Group
Type
journal article