The Impact of Dialysis-Requiring Acute Kidney Injury on Long-Term Prognosis of Patients Requiring Prolonged Mechanical Ventilation: Nationwide Population-Based Study
Journal
PLoS ONE
Journal Volume
7
Journal Issue
12
Pages
e50675
Date Issued
2012
Author(s)
Abstract
Background: Prolonged mechanical ventilation (PMV) is increasingly common worldwide, consuming enormous healthcare resources. Factors that modify PMV outcome are still obscure. Methods: We selected patients without preceding mechanical ventilation within the one past year and who developed PMV during index admission in Taiwan's National Health Insurance (NHI) system during 1998-2007 for comparison of mortality and resource use. They were divided into three groups: (1) patients with end-stage renal diseases (ESRD) before the index admission for PMV onset; (2) patients with dialysis-requiring acute kidney injury (AKI-dialysis) during the hospitalization course; and (3) patients without AKI or with non dialysis-requiring AKI during the hospitalization course (non-AKI). We used a random-effects logistic regression model to identify factors associated with mortality. Results: Compared with the other two groups, patients with AKI-dialysis had significantly longer mechanical ventilation, more frequent use of vasopressors, longer intensive care unit/hospital stay and higher inpatient expenditures during the index admission. Relative to non-AKI patients, patients with AKI-dialysis had an elevated mortality hazard; the adjusted relative risk ratios were 1.51 (95% confidence interval [CI]:1.46-1.56), 1.27 (95% CI: 1.23-1.32), and 1.10 (95% CI: 1.08-1.12) for mortality rates at discharge, 3 months, and 4 years after PMV, respectively. Patients with AKI-dialysis also consumed significantly higher total in-patient expenditure than the other two patient groups (p<0.001). Conclusions: Among patients that need PMV care during an admission, the presence of de novo AKI requiring dialysis significantly increased short and long term mortality, and demand for health care resources. ? 2012 Chao et al.
SDGs
Other Subjects
hypertensive factor; acute kidney failure; adult; aged; article; artificial ventilation; controlled study; dialysis; female; health care cost; health care utilization; hospital discharge; hospitalization; human; intensive care; kidney function; length of stay; major clinical study; male; mortality; prognosis; prolonged mechanical ventilation; renal replacement therapy; retrospective study; Acute Kidney Injury; Aged; Aged, 80 and over; Female; Health Care Costs; Health Surveys; Hospital Mortality; Humans; Intensive Care; Intensive Care Units; Kidney Failure, Chronic; Length of Stay; Male; Middle Aged; Prognosis; Renal Dialysis; Respiration, Artificial; Retrospective Studies; Risk Factors; Taiwan; Treatment Outcome; Papaya mosaic virus
Type
journal article