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  4. Advanced age affects the outcome-predictive power of RIFLE classification in geriatric patients with acute kidney injury
 
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Advanced age affects the outcome-predictive power of RIFLE classification in geriatric patients with acute kidney injury

Journal
Kidney International
Journal Volume
82
Journal Issue
8
Pages
920-927
Date Issued
2012
Author(s)
CHIA-TER CHAO  
VIN-CENT WU  orcid-logo
CHUN-FU LAI  
Shiao C.-C.
TAO-MIN HUANG  
Wu P.-C.
I-JUNG TSAI  
Hou C.-C.
Wang W.-J.
HUNG-BIN TSAI  
YU-FENG LIN  
WEN-CHIH CHIANG  
SHUEI-LIONG LIN  
Tsai P.-R.
Ko W-J.
MING-SHIOU WU  
KWAN-DUN WU  
DOI
10.1038/ki.2012.237
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867094707&doi=10.1038%2fki.2012.237&partnerID=40&md5=7c649e924cae6b9ef9a61d27ac41c802
https://scholars.lib.ntu.edu.tw/handle/123456789/515124
Abstract
The RIFLE (risk, injury, failure, loss, and end-stage) classification is widely used to gauge the severity of acute kidney injury, but its efficacy has not been formally tested in geriatric patients. To correct this we conducted a prospective observational study in a multicenter cohort of 3931 elderly patients (65 years of age or older) who developed acute kidney injury in accordance with the RIFLE creatinine criteria after major surgery. We studied the predictive power of the RIFLE classification for in-hospital mortality and investigated the potential interaction between age and RIFLE classification. In general, the survivors were significantly younger than the nonsurvivors and more likely to have hypertension. In patients 76 years of age and younger, RIFLE-R,-I, or-F classifications were significantly associated with increased hospital mortality in a stepwise manner. There was no significant difference, however, in hospital mortality in those over 76 years of age between patients with RIFLE-R and RIFLE-I, although RIFLE-F patients had significantly higher mortality than both groups. Thus, the less severe categorizations of acute kidney injury per RIFLE classification may not truly reflect the adverse impact on elderly patients. ? 2012 International Society of Nephrology.
SDGs

[SDGs]SDG3

Other Subjects
creatinine; acute kidney failure; age distribution; aged; aging; article; chronic hepatitis; chronic obstructive lung disease; clinical assessment tool; cohort analysis; comorbidity; controlled study; coronary artery disease; creatinine blood level; diabetes mellitus; disease association; disease classification; female; geriatric patient; heart failure; human; hypertension; kidney failure; liver cirrhosis; major clinical study; male; malignant neoplastic disease; mortality; multicenter study; observational study; outcome assessment; predictive value; priority journal; prognosis; risk factor; Risk, Injury, Failure, Loss, and End stage classificaten; sensitivity analysis; survival rate
Publisher
Nature Publishing Group
Type
journal article

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