|Title:||Change of both endocrine and exocrine insufficiencies after acute pancreatitis in non-diabetic patients||Authors:||Ho, Te-Wei
|Issue Date:||9-Jul-2015||Journal Volume:||94||Journal Issue:||27||Source:||Medicine (United States)||Abstract:||
Acute pancreatitis (AP) is the most common pancreatic disease and consists of an acute inflammation of the pancreas. AP can contribute to endocrine and exocrine insufficiencies in survivors as a result of the key role of the pancreas in both glucose metabolism and nutritional digestion. The aim of this population-based study was to determine the endocrine or exocrine insufficiencies in patients after initial AP with biliary or alcohol-associated causes. We conducted a nationwide cohort study using data from Taiwan's National Health Insurance Research Database collected between 2001 and 2010. A total of 12,284 patients with AP were identified. Alcohol-associated AP (odds ratio, 1.894; 95% CI, 1.520-2.268; P<0.001) and ?2 admissions for AP (odds ratio, 1.937; 95% CI, 1.483-2.391; P<0.001) were significantly associated with newly diagnosed diabetes mellitus after AP. Further, only alcohol-associated AP (odds ratio, 1.215; 95% CI, 1.133-1.297; P<0.001) was significantly associated with pancreatic exocrine insufficiency after AP. Additionally, alcohol-associated AP (odds ratio, 1.804; 95% CI, 1.345-2.263; P<0.001) and ?2 readmissions for AP (odds ratio, 3.190; 95% CI, 2.317-4.063; P<0.001) were significantly associated with both exocrine and endocrine insufficiencies after AP. Our data showed that alcohol-associated AP, rather than a biliary cause, contributed to a higher extent to exocrine or endocrine insufficiencies. Furthermore, recurrent AP also led to endocrine insufficiency. ? 2015 Wolters Kluwer Health, Inc.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/515672||ISSN:||0025-7974||DOI:||10.1097/MD.0000000000001123||SDG/Keyword:||pancreas enzyme; acute pancreatitis; adult; aged; Article; Charlson Comorbidity Index; cohort analysis; comorbidity; diabetes mellitus; digestion; disease severity; endocrine disease; female; follow up; glucose metabolism; hospital readmission; human; major clinical study; male; middle aged; pancreas exocrine insufficiency; pancreas function; pancreatic stellate cell; population research; priority journal; retrospective study; Taiwan; acute disease; age; alcoholic pancreatitis; complication; diabetes mellitus; epidemiology; Exocrine Pancreatic Insufficiency; incidence; pancreatitis; pathophysiology; sex difference; time; Acute Disease; Age Factors; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus; Exocrine Pancreatic Insufficiency; Female; Humans; Incidence; Male; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic; Sex Factors; Taiwan; Time Factors
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.