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  4. Change of both endocrine and exocrine insufficiencies after acute pancreatitis in non-diabetic patients
 
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Change of both endocrine and exocrine insufficiencies after acute pancreatitis in non-diabetic patients

Journal
Medicine (United States)
Journal Volume
94
Journal Issue
27
Date Issued
2015-07-09
Author(s)
Ho, Te-Wei
JIN-MING WU  
TING-CHUN KUO  
CHING-YAO YANG  
HONG-SHIEE LAI  
Hsieh, Su-Hua
FEI-PEI LAI  
YU-WEN TIEN  
DOI
10.1097/MD.0000000000001123
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/515672
Abstract
Acute pancreatitis (AP) is the most common pancreatic disease and consists of an acute inflammation of the pancreas. AP can contribute to endocrine and exocrine insufficiencies in survivors as a result of the key role of the pancreas in both glucose metabolism and nutritional digestion. The aim of this population-based study was to determine the endocrine or exocrine insufficiencies in patients after initial AP with biliary or alcohol-associated causes. We conducted a nationwide cohort study using data from Taiwan's National Health Insurance Research Database collected between 2001 and 2010. A total of 12,284 patients with AP were identified. Alcohol-associated AP (odds ratio, 1.894; 95% CI, 1.520-2.268; P<0.001) and ?2 admissions for AP (odds ratio, 1.937; 95% CI, 1.483-2.391; P<0.001) were significantly associated with newly diagnosed diabetes mellitus after AP. Further, only alcohol-associated AP (odds ratio, 1.215; 95% CI, 1.133-1.297; P<0.001) was significantly associated with pancreatic exocrine insufficiency after AP. Additionally, alcohol-associated AP (odds ratio, 1.804; 95% CI, 1.345-2.263; P<0.001) and ?2 readmissions for AP (odds ratio, 3.190; 95% CI, 2.317-4.063; P<0.001) were significantly associated with both exocrine and endocrine insufficiencies after AP. Our data showed that alcohol-associated AP, rather than a biliary cause, contributed to a higher extent to exocrine or endocrine insufficiencies. Furthermore, recurrent AP also led to endocrine insufficiency. ? 2015 Wolters Kluwer Health, Inc.
SDGs

[SDGs]SDG3

Other Subjects
pancreas enzyme; acute pancreatitis; adult; aged; Article; Charlson Comorbidity Index; cohort analysis; comorbidity; diabetes mellitus; digestion; disease severity; endocrine disease; female; follow up; glucose metabolism; hospital readmission; human; major clinical study; male; middle aged; pancreas exocrine insufficiency; pancreas function; pancreatic stellate cell; population research; priority journal; retrospective study; Taiwan; acute disease; age; alcoholic pancreatitis; complication; diabetes mellitus; epidemiology; Exocrine Pancreatic Insufficiency; incidence; pancreatitis; pathophysiology; sex difference; time; Acute Disease; Age Factors; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus; Exocrine Pancreatic Insufficiency; Female; Humans; Incidence; Male; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic; Sex Factors; Taiwan; Time Factors
Type
journal article

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