https://scholars.lib.ntu.edu.tw/handle/123456789/515673
標題: | Glycemic Change After Pancreaticoduodenectomy | 作者: | JIN-MING WU Ho, Te-Wei TING-CHUN KUO CHING-YAO YANG HONG-SHIEE LAI Chiang, Pin-Yi Hsieh, Su-Hua FEI-PEI LAI YU-WEN TIEN |
公開日期: | 9-七月-2015 | 卷: | 94 | 期: | 27 | 來源出版物: | Medicine (United States) | 摘要: | The purpose of this population-based study was to determine the change of glucose metabolism in patients undergoing pancreaticoduodenectomy (PD). We conducted a nationwide cohort study using data from Taiwan's National Health Insurance Research Database collected between 2000 and 2010. Our sample included 861 subjects with type 2 diabetes mellitus (DM) and 3914 subjects without DM. Of 861 subjects with type 2 diabetes, 174 patients (20.2%) experienced resolution of their diabetes after PD, including patients with pancreatic ductal adenocarcinoma (PDAC) (20.5%), and non-PDAC (20.1%). Using a multiple logistic regression model, we found that subjects with comorbid chronic pancreatitis (odds ratio, 0.356; 95% CI, 0.167-0.759; P=0.007) and use of insulin (odds ratio, 0.265; 95% CI, 0.171-0.412; P<0.001) had significantly lower rates of resolution of diabetes. In the 3914 subjects without diabetes, the only statistically significant comorbidity contributing to pancreatogenic diabetes was chronic pancreatitis (odds ratio, 1.446; 95% CI, 1.146-1.823; P=0.002). Subjects with comorbid chronic pancreatitis and use of insulin had lower rates of resolution of DM after PD. In subjects without diabetes, chronic pancreatitis contributed significantly to the development of pancreatogenic DM. ? 2015 Wolters Kluwer Health, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/515673 | ISSN: | 0025-7974 | DOI: | 10.1097/MD.0000000000001109 | SDG/關鍵字: | glucose; insulin; adult; aged; Article; chronic pancreatitis; cohort analysis; controlled study; diabetic patient; female; glucose metabolism; human; insulin treatment; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; pancreas adenocarcinoma; pancreaticoduodenectomy; priority journal; metabolism; non insulin dependent diabetes mellitus; Pancreatic Neoplasms; pancreaticoduodenectomy; procedures; Taiwan; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Pancreatic Neoplasms; Pancreaticoduodenectomy; Pancreatitis, Chronic; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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