https://scholars.lib.ntu.edu.tw/handle/123456789/515764
標題: | Estimated risk of cardiovascular disease among the HIV-positive patients aged 40 years or older in Taiwan | 作者: | Wu P.-Y. Chen M.-Y. WANG-HUEI SHENG SZU-MIN HSIEH YU-CHUNG CHUANG ARISTINE CHENG SUNG-CHING PAN UN-IN WU Chang H.-Y. Luo Y.-Z. Yang S.-P. Zhang J.-Y. HSIN-YUN SUN CHIEN-CHING HUNG |
公開日期: | 2019 | 出版社: | Elsevier Ltd | 卷: | 52 | 期: | 4 | 起(迄)頁: | 549-555 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background: Cardiovascular disease (CVD) is an emerging cause of morbidity and mortality among HIV-positive patients receiving successful combination antiretroviral therapy, but their CVD risk has been rarely investigated in Asia–Pacific region. We aimed to assess the CVD risk of HIV-positive Taiwanese outpatients. Methods: We did cross-sectional questionnaire interviews to collect information of HIV-positive Taiwanese patients aged 40–79 at the HIV clinics of a medical center from 1 March to 31 August, 2017. The Framingham Risk Score (FRS), Atherosclerotic Cardiovascular Disease (ASCVD) risk score and Data-Collection on Adverse effects of Anti-HIV Drugs (D:A:D) risk score were used to estimate their CVD risk. Results: Of the screened 1251 patients, 1006 (80.4%) with complete data to assess their CVD risk were included for analyses. The prevalence of patients aged 40–75 and with a high CVD risk was 30.6% by FRS, 3.7% by D:A:D (R) risk score, and 22.2% by ASCVD risk score. In multiple logistic regression, older age, current smoking, higher systolic blood pressure, and higher triglyceride and fasting glucose levels were independently associated with the ASCVD risk score ?7.5%. If current smokers aged 55–59 had stopped smoking, the proportions of them with a 10-year CVD risk of ?10% by FRS and ?7.5% by ASCVD risk score would have decreased by 35.3% and 20.0%, respectively. Conclusions: Higher CVD risk estimates among HIV-positive Taiwanese aged 40–75 were associated with an older age, current smoking, higher systolic blood pressure, hypertriglyceridemia, and hyperglycemia. Smoking cessation could potentially lead to significant decreases of CVD risk. ? 2019 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064600472&doi=10.1016%2fj.jmii.2019.03.006&partnerID=40&md5=fd00657123a6df0b8624cc29b918ead4 https://scholars.lib.ntu.edu.tw/handle/123456789/515764 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2019.03.006 | SDG/關鍵字: | anti human immunodeficiency virus agent; antidiabetic agent; antihypertensive agent; antilipemic agent; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; aged; antiretroviral therapy; Article; cardiovascular disease; cardiovascular risk; CD4 lymphocyte count; cholesterol blood level; coronary artery atherosclerosis; cross-sectional study; diastolic blood pressure; female; follow up; Framingham risk score; glucose level; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hyperglycemia; hypertension; hypertriglyceridemia; major clinical study; male; risk reduction; smoking; smoking cessation; systolic blood pressure; Taiwanese; virus load; atherosclerosis; cardiovascular disease; comorbidity; complication; epidemiology; hypertension; middle aged; prevalence; questionnaire; risk assessment; risk factor; statistical model; Taiwan; Adult; Aged; Anti-HIV Agents; Atherosclerosis; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Hypertension; Logistic Models; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Smoking; Surveys and Questionnaires; Taiwan |
顯示於: | 醫學系 |
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